Automated description from the Alliance of Genome Resources (Release 5.3.0)
Enables serine-type endopeptidase activity. Involved in trans-synaptic signaling by BDNF, modulating synaptic transmission. Acts upstream of or within several processes, including platelet-derived growth factor receptor signaling pathway; response to hypoxia; and smooth muscle cell migration. Located in apical part of cell; extracellular space; and secretory granule. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and integumental system. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and thrombophilia (multiple). Orthologous to human PLAT (plasminogen activator, tissue type).