Automated description from the Alliance of Genome Resources (Release 3.0)
Exhibits serine-type endopeptidase activity. Involved in several processes, including platelet-derived growth factor receptor signaling pathway; smooth muscle cell migration; and trans-synaptic signaling by BDNF, modulating synaptic transmission. Localizes to several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and secretory granule. Human ortholog(s) of this gene implicated in several diseases, including antiphospholipid syndrome; diabetic angiopathy; factor VIII deficiency; osteonecrosis; and thrombophilia (multiple). Is expressed in several structures, including central nervous system; liver; surface ectoderm; testis; and urinary system. Orthologous to human PLAT (plasminogen activator, tissue type).