Automated description from the Alliance of Genome Resources (Release 3.1)
Exhibits calcium channel activity. Involved in several processes, including animal organ development; cytoplasmic sequestering of transcription factor; and receptor signaling pathway via JAK-STAT. Localizes to several cellular components, including Golgi apparatus; motile cilium; and polycystin complex. Is expressed in several structures, including cardiovascular system; central nervous system; embryo mesenchyme; metanephros; and respiratory system. Used to study autosomal recessive polycystic kidney disease; hypertrophic cardiomyopathy; and polycystic kidney disease 1. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; and polycystic kidney disease 1. Orthologous to human PKD1 (polycystin 1, transient receptor potential channel interacting).