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Gene Ontology Classifications
Symbol
Name
ID
Pou1f1
POU domain, class 1, transcription factor 1
MGI:97588

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pou1f1. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein regulates expression of several genes involved in pituitary development and hormone expression. Mutations in this genes result in combined pituitary hormone deficiency. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Andersen B et al. (1993) Sperm 1: a POU-domain gene transiently expressed immediately before meiosis I in the male germ cell. Proc Natl Acad Sci U S A, 90:11084-8. (PubMed:7902581)
  2. Bach I et al. (1999) RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex. Nat Genet, 22:394-9. (PubMed:10431247)
  3. Cheng TC et al. (1983) Etiology of growth hormone deficiency in little, Ames, and Snell dwarf mice. Endocrinology, 113:1669-78. (PubMed:6194978)
  4. Dasen JS et al. (1999) Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types. Cell, 97:587-98. (PubMed:10367888)
  5. Flurkey K et al. (2001) Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci U S A, 98:6736-41. (PubMed:11371619)
  6. Gonzalez MM et al. (2002) Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors. J Biol Chem, 277:18501-9. (PubMed:11891224)
  7. Gordon DF et al. (1997) Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin beta-subunit promoter. J Biol Chem, 272:24339-47. (PubMed:9305891)
  8. Lin C et al. (1992) Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth [see comments] Nature, 360:765-8. (PubMed:1334535)
  9. Lin SC et al. (1993) Molecular basis of the little mouse phenotype and implications for cell type-specific growth [see comments] Nature, 364:208-13. (PubMed:8391647)
  10. Liu J et al. (2001) Tbx19, a tissue-selective regulator of POMC gene expression. Proc Natl Acad Sci U S A, 98:8674-9. (PubMed:11447259)
  11. Montecino-Rodriguez E et al. (1997) Primary B cell development is impaired in mice with defects of the pituitary/thyroid axis. J Immunol, 159:2712-9. (PubMed:9300691)
  12. Nissley SP et al. (1980) Somatomedin activity in sera of genetically small mice. Horm Metab Res, 12:158-64. (PubMed:7390396)
  13. Olson LE et al. (2006) Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell, 125:593-605. (PubMed:16678101)
  14. Pulichino AM et al. (2003) Tpit determines alternate fates during pituitary cell differentiation. Genes Dev, 17:738-47. (PubMed:12651892)
  15. Wang J et al. (2007) Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature, 446:882-7. (PubMed:17392792)
  16. Ward RD et al. (2006) Cell proliferation and vascularization in mouse models of pituitary hormone deficiency. Mol Endocrinol, 20:1378-90. (PubMed:16556738)
  17. Zhu X et al. (2006) Sustained Notch signaling in progenitors is required for sequential emergence of distinct cell lineages during organogenesis. Genes Dev, 20:2739-53. (PubMed:17015435)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory