Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Phka1. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, and the skeletal muscle isoform is encoded by this gene. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, which are encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9D, also known as X-linked muscle glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. A pseudogene has been found on chromosome 1.[provided by RefSeq, Feb 2010]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Phka1:
  • participates in the following biological processes:
    • protein autophosphorylation
  • performs the following molecular functions:
    • phosphorylase kinase activity
  • is located in the following cellular components:
    • phosphorylase kinase complex

---

Summary text based on GO annotations supported by structural data

• Phka1 encodes a protein or proteins that contain the following InterPro domains: Glycoside hydrolase family 15, Phosphorylase kinase alpha/beta subunit, Six-hairpin glycosidase, Six-hairpin glycosidase-like, indicating that the gene product:
  • participates in the following biological processes:
    • glycogen metabolic process
    • polysaccharide metabolic process
  • performs the following molecular functions:
    • calmodulin binding
    • catalytic activity
    • hydrolase activity, hydrolyzing O-glycosyl compounds

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Phka1 indicates that it:
  • participates in the following biological processes:
    • carbohydrate metabolic process
    • glycogen metabolic process
    • phosphorylation
  • performs the following molecular functions:
    • calmodulin binding
    • kinase activity
  • is located in the following cellular components:
    • membrane
    • plasma membrane

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---