Automated description from the Alliance of Genome Resources (Release 5.2.2)
Enables transcription corepressor activity. Involved in several processes, including CD40 signaling pathway; activation of phospholipase C activity; and positive regulation of macromolecule metabolic process. Acts upstream of or within DNA biosynthetic process and negative regulation of transcription by RNA polymerase II. Located in several cellular components, including cell surface; mitochondrial inner membrane; and nucleus. Part of mitochondrial prohibitin complex. Is expressed in ectoplacental cone; embryo; and extraembryonic ectoderm. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB1 (prohibitin 1).