Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables transcription corepressor activity. Involved in several processes, including CD40 signaling pathway; modulation by host of viral RNA genome replication; and positive regulation of non-canonical NF-kappaB signal transduction. Acts upstream of or within DNA biosynthetic process and negative regulation of transcription by RNA polymerase II. Located in several cellular components, including cell surface; mitochondrial inner membrane; and nucleus. Part of mitochondrial prohibitin complex. Is expressed in cerebral cortex ventricular layer; cortical plate; ectoplacental cone; embryo; and extraembryonic ectoderm. Human ortholog(s) of this gene implicated in breast cancer and sporadic breast cancer. Orthologous to human PHB1 (prohibitin 1).