Automated description from the Alliance of Genome Resources (Release 3.0)
Exhibits ATPase activity, coupled; ATPase-coupled intramembrane lipid transporter activity; and transmembrane transporter activity. Involved in lipid translocation; xenobiotic detoxification by transmembrane export across the plasma membrane; and xenobiotic transport across blood-brain barrier. Localizes to apical plasma membrane and intercellular canaliculus. Used to study inflammatory bowel disease 13. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; allergic rhinitis; carcinoma (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and integumental system. Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1).