Automated description from the Alliance of Genome Resources
Exhibits ATPase activity, coupled; ATPase-coupled intramembrane lipid transporter activity; and ATPase-coupled xenobiotic transmembrane transporter activity. Involved in ceramide translocation; phospholipid translocation; and xenobiotic detoxification by transmembrane export across the plasma membrane. Localizes to the apical plasma membrane and intercellular canaliculus. Used to study inflammatory bowel disease 13. Human ortholog(s) of this gene implicated in several diseases, including Behcet's disease; allergic rhinitis; carcinoma (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1).