Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Abcb4. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Abcb4
  • is located in the following cellular components:
    • intercellular canaliculus ^[1]
    • membrane ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Abcb4:
  • participates in the following biological processes:
    • transmembrane transport
  • performs the following molecular functions:
    • ATPase activity, coupled to transmembrane movement of substances
  • is located in the following cellular components:
    • apical plasma membrane
    • Golgi membrane
    • integral to membrane

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Summary text based on GO annotations supported by structural data

• Abcb4 encodes a protein or proteins that contain the following InterPro domains: AAA+ ATPase domain, ABC transporter, conserved site, ABC transporter, integral membrane type 1, ABC transporter, transmembrane domain, ABC transporter, transmembrane domain, type 1, ABC transporter-like, indicating that the gene product:
  • participates in the following biological processes:
    • ATP catabolic process
    • metabolic process
    • transport
  • performs the following molecular functions:
    • ATP binding
    • ATPase activity
    • nucleoside-triphosphatase activity
    • nucleotide binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Abcb4 indicates that it:
  • participates in the following biological processes:
    • metabolic process
    • transport
  • performs the following molecular functions:
    • ATP binding
    • hydrolase activity
    • nucleotide binding
  • is located in the following cellular components:
    • plasma membrane
• Abcb4 has been associated with the Enzyme Commission numbers: 3.6.3.44, which implies that the gene product:
  • participates in the following biological processes:
    • ATP catabolic process
    • drug transmembrane transport
    • xenobiotic transport
  • performs the following molecular functions:
    • xenobiotic-transporting ATPase activity

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References

1. Kikuchi S et al. (2002) Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes. Nat Genet, 31:320-5. (PubMed:12068294)
2. Shih DQ et al. (2001) Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Nat Genet, 27:375-82. (PubMed:11279518)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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