Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits Rho GTPase binding activity. Involved in neural tube closure; regulation of transcription by RNA polymerase II; and synapse organization. Localizes to cytoplasm; glutamatergic synapse; and nucleus. Is expressed in several structures, including heart; hemolymphoid system; liver; lung; and metanephros. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 18. Orthologous to human PFN1 (profilin 1).