Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pfn1. (This text reflects annotations as of Thursday, July 24, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Pfn1
  • is located in the following cellular components:
    • cytoplasm ^[6]
    • nucleus ^[3]
• The gene product of Pfn1 has been shown to bind to the gene products of Mypop. ^{[1, 3, 4]} Researchers have inferred, based on physical interactions, that the gene product of Pfn1
  • performs the following molecular functions:
    • Rho GTPase binding ^[5]
• Researchers have inferred, based on genetic interactions, that the gene product of Pfn1
  • participates in the following biological processes:
    • neural tube closure based on interactions with Enah ^[2]
    • regulation of transcription from RNA polymerase II promoter based on interactions with Mypop ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Pfn1:
  • participates in the following biological processes:
    • negative regulation of actin filament bundle assembly
    • negative regulation of actin filament polymerization
    • negative regulation of stress fiber assembly
    • positive regulation of actin filament polymerization
    • positive regulation of ATPase activity
    • positive regulation of DNA metabolic process
    • positive regulation of epithelial cell migration
    • positive regulation of ruffle assembly
    • positive regulation of stress fiber assembly
    • positive regulation of transcription from RNA polymerase II promoter
    • positive regulation of viral transcription
  • performs the following molecular functions:
    • actin binding
    • adenyl-nucleotide exchange factor activity
    • phosphatidylinositol-4,5-bisphosphate binding
    • poly(A) RNA binding
    • proline-rich region binding
    • receptor binding
  • is located in the following cellular components:
    • blood microparticle
    • cytoplasm
    • extracellular vesicular exosome
    • membrane
    • neuron projection
    • synapse

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Summary text based on GO annotations supported by structural data

• Pfn1 encodes a protein or proteins that contain the following InterPro domains: Profilin, Profilin conserved site, Profilin, chordates, indicating that the gene product:
  • participates in the following biological processes:
    • actin cytoskeleton organization

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Pfn1 indicates that it:
  • is located in the following cellular components:
    • cytoskeleton

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References

1. Kanaujiya JK et al. (2013) Proteomic identification of Profilin1 as a corepressor of estrogen receptor alpha in MCF7 breast cancer cells. Proteomics, 13:2100-12. (PubMed:23576398)
2. Lanier LM et al. (1999) Mena is required for neurulation and commissure formation. Neuron, 22:313-25. (PubMed:10069337)
3. Lederer M et al. (2005) Profilin regulates the activity of p42POP, a novel Myb-related transcription factor. J Cell Sci, 118:331-41. (PubMed:15615774)
4. Miyagi Y et al. (2002) Delphilin: a novel PDZ and formin homology domain-containing protein that synaptically colocalizes and interacts with glutamate receptor delta 2 subunit. J Neurosci, 22:803-14. (PubMed:11826110)
5. Murphy GA et al. (1999) Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth. Oncogene, 18:3831-45. (PubMed:10445846)
6. Witke W et al. (2001) Profilin I is essential for cell survival and cell division in early mouse development. Proc Natl Acad Sci U S A, 98:3832-6. (PubMed:11274401)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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