Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pepd. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Pepd
  • participates in the following biological processes:
    • metabolic process ^[1]
  • performs the following molecular functions:
    • peptidase activity ^[1]

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Summary text based on GO annotations supported by structural data

• Pepd encodes a protein or proteins that contain the following InterPro domains: Aminopeptidase P N-terminal domain, Peptidase M24, structural domain, Peptidase M24B, X-Pro dipeptidase/aminopeptidase P, conserved site, indicating that the gene product:
  • participates in the following biological processes:
    • cellular process
  • performs the following molecular functions:
    • aminopeptidase activity
    • manganese ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Pepd indicates that it:
  • participates in the following biological processes:
    • collagen catabolic process
    • proteolysis
  • performs the following molecular functions:
    • dipeptidase activity
    • hydrolase activity
    • metal ion binding
    • metallopeptidase activity

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References

1. Lewis WH et al. (1969) Electrophoretic heterogeneity of mouse erythrocyte peptidases. Biochem Genet, 3:493-8. (PubMed:4187938)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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