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Gene Ontology Classifications
platelet/endothelial cell adhesion molecule 1

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GO curators for mouse genes have assigned the following annotations to the gene product of Pecam1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Cao MY et al. (1999) Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells. J Exp Med, 190:1527-34. (PubMed:10562326)
  2. Crippa S et al. (2011) miR669a and miR669q prevent skeletal muscle differentiation in postnatal cardiac progenitors. J Cell Biol, 193:1197-212. (PubMed:21708977)
  3. Davies BS et al. (2010) GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries. Cell Metab, 12:42-52. (PubMed:20620994)
  4. Gratzinger D et al. (2003) Platelet endothelial cell adhesion molecule-1 modulates endothelial cell motility through the small G-protein Rho. FASEB J, 17:1458-69. (PubMed:12890700)
  5. Ilan N et al. (2001) Pecam-1 is a modulator of stat family member phosphorylation and localization: lessons from a transgenic mouse. Dev Biol, 232:219-32. (PubMed:11254359)
  6. Moreno-Barriuso N et al. (2006) Alterations in alveolar epithelium differentiation and vasculogenesis in lungs of LIF/IGF-I double deficient embryos Dev Dyn, 235:2040-50. (PubMed:16691571)
  7. Ogata T et al. (2008) MURC, a muscle-restricted coiled-coil protein that modulates the Rho/ROCK pathway, induces cardiac dysfunction and conduction disturbance. Mol Cell Biol, 28:3424-36. (PubMed:18332105)
  8. Osorio KM et al. (2011) Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J Cell Biol, 193:235-50. (PubMed:21464233)
  9. Proctor JM et al. (2005) Vascular development of the brain requires beta8 integrin expression in the neuroepithelium. J Neurosci, 25:9940-8. (PubMed:16251442)
  10. Takayanagi S et al. (2006) Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain. Blood, 107:4317-25. (PubMed:16455951)
  11. Wakayama T et al. (2003) The expression of platelet endothelial cell adhesion molecule-1 in mouse primordial germ cells during their migration and early gonadal formation. Histochem Cell Biol, 119:355-62. (PubMed:12736726)
  12. Zotes TM et al. (2013) PI3K p110delta is expressed by gp38(-)CD31(+) and gp38(+)CD31(+) spleen stromal cells and regulates their CCL19, CCL21, and LTbetaR mRNA levels. PLoS One, 8:e72960. (PubMed:24009720)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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