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Gene Ontology Classifications
Symbol
Name
ID
Pdgfrb
platelet derived growth factor receptor, beta polypeptide
MGI:97531

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pdgfrb. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Alonso G et al. (1995) Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors. J Biol Chem, 270:9840-8. (PubMed:7730365)
  2. Fukumoto Y et al. (2011) Role of scaffold protein afadin dilute domain-interacting protein (ADIP) in platelet-derived growth factor-induced cell movement by activating Rac protein through Vav2 protein. J Biol Chem, 286:43537-48. (PubMed:22027834)
  3. Hellstrom M et al. (1999) Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development, 126:3047-55. (PubMed:10375497)
  4. Holgado-Madruga M et al. (2003) Gab1 is an integrator of cell death versus cell survival signals in oxidative stress. Mol Cell Biol, 23:4471-84. (PubMed:12808090)
  5. King SJ et al. (2011) beta1 integrins regulate fibroblast chemotaxis through control of N-WASP stability. EMBO J, 30:1705-18. (PubMed:21427700)
  6. Klinghoffer RA et al. (2001) The two PDGF receptors maintain conserved signaling in vivo despite divergent embryological functions. Mol Cell, 7:343-54. (PubMed:11239463)
  7. Lindahl P et al. (1998) Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli. Development, 125:3313-22. (PubMed:9693135)
  8. Markova B et al. (2003) Identification of protein tyrosine phosphatases associating with the PDGF receptor. Biochemistry, 42:2691-9. (PubMed:12614164)
  9. Mertins P et al. (2008) Investigation of protein-tyrosine phosphatase 1B function by quantitative proteomics. Mol Cell Proteomics, 7:1763-77. (PubMed:18515860)
  10. Nagamachi A et al. (2013) Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Cancer Cell, 24:305-17. (PubMed:24029230)
  11. Ricono JM et al. (2009) PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA. Am J Physiol Renal Physiol, 296:F406-17. (PubMed:19019919)
  12. Riedel H et al. (2000) PSM, a mediator of PDGF-BB-, IGF-I-, and insulin-stimulated mitogenesis. Oncogene, 19:39-50. (PubMed:10644978)
  13. Saito Y et al. (2002) Protein kinase C-alpha and protein kinase C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor. J Biol Chem, 277:23216-22. (PubMed:11940581)
  14. Schmahl J et al. (2008) The PDGF signaling pathway controls multiple steroid-producing lineages. Genes Dev, 22:3255-67. (PubMed:19056881)
  15. Schmahl J et al. (2007) PDGF signaling specificity is mediated through multiple immediate early genes. Nat Genet, 39:52-60. (PubMed:17143286)
  16. Takahashi Y et al. (2006) PTEN tumor suppressor associates with NHERF proteins to attenuate PDGF receptor signaling. EMBO J, 25:910-20. (PubMed:16456542)
  17. Tallquist MD et al. (2003) Additive Effects of PDGF Receptor beta Signaling Pathways in Vascular Smooth Muscle Cell Development. PLoS Biol, 1:288-99. (PubMed:14624252)
  18. Wagner B et al. (2007) Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells. J Am Soc Nephrol, 18:2903-11. (PubMed:17942966)
  19. Zhou L et al. (2009) LRP1 regulates architecture of the vascular wall by controlling PDGFRbeta-dependent phosphatidylinositol 3-kinase activation. PLoS One, 4:e6922. (PubMed:19742316)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory