Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits platelet-derived growth factor-activated receptor activity and signaling receptor binding activity. Involved in several processes, including animal organ development; positive regulation of intracellular signal transduction; and vasculature development. Localizes to cell surface; cytoplasm; and ruffle. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Used to study basal ganglia calcification; infantile myofibromatosis; myeloproliferative neoplasm; and severe nonproliferative diabetic retinopathy. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma multiforme; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta).