Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Pde6g. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the gamma subunit of cyclic GMP-phosphodiesterase, which is composed of alpha- and beta- catalytic subunits and two identical, inhibitory gamma subunits. This gene is expressed in rod photoreceptors and functions in the phototransduction signaling cascade. It is also expressed in a variety of other tissues, and has been shown to regulate the c-Src protein kinase and G-protein-coupled receptor kinase 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Pde6g
  • participates in the following biological processes:
    • activation of MAPK activity ^[1]
    • positive regulation of epidermal growth factor receptor signaling pathway ^[1]
    • positive regulation of G-protein coupled receptor protein signaling pathway ^[1]
• The gene product of Pde6g has been shown to bind to the gene products of Dnm2. ^[1]

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Summary text based on GO annotations supported by structural data

• Pde6g encodes a protein or proteins that contain the following InterPro domains: Retinal cGMP phosphodiesterase, gamma subunit, indicating that the gene product:
  • participates in the following biological processes:
    • visual perception
  • performs the following molecular functions:
    • 3',5'-cyclic-nucleotide phosphodiesterase activity
    • cGMP binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Pde6g indicates that it:
  • participates in the following biological processes:
    • response to stimulus
    • visual perception
  • performs the following molecular functions:
    • hydrolase activity
• Pde6g has been associated with the Enzyme Commission numbers: 3.1.4.35, which implies that the gene product:
  • performs the following molecular functions:
    • 3',5'-cyclic-GMP phosphodiesterase activity

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References

1. Wan KF et al. (2001) The inhibitory gamma subunit of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase is a novel intermediate regulating p42/p44 mitogen-activated protein kinase signaling in human embryonic kidney 293 cells. J Biol Chem, 276:37802-8. (PubMed:11502744)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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