Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Furin. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Furin
  • participates in the following biological processes:
    • protein processing ^[3]
    • regulation of signal transduction ^[1]
• The gene product of Furin has been shown to bind to the gene products of Flna. ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Furin:
  • participates in the following biological processes:
    • cell proliferation
    • negative regulation of low-density lipoprotein particle receptor catabolic process
    • negative regulation of transforming growth factor beta1 production
    • nerve growth factor production
    • peptide biosynthetic process
    • peptide hormone processing
    • positive regulation of cell migration
    • positive regulation of transforming growth factor beta receptor signaling pathway
    • protein processing
    • regulation of endopeptidase activity
    • regulation of protein catabolic process
    • secretion by cell
    • signal peptide processing
  • performs the following molecular functions:
    • endopeptidase activity
    • nerve growth factor binding
    • peptidase activity
    • peptide binding
    • protease binding
    • serine-type endopeptidase activity
    • serine-type endopeptidase inhibitor activity
  • is located in the following cellular components:
    • cell surface
    • endoplasmic reticulum membrane
    • extracellular space
    • Golgi apparatus
    • Golgi cisterna
    • membrane raft
    • plasma membrane
    • trans-Golgi network
    • trans-Golgi network transport vesicle

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Summary text based on GO annotations supported by structural data

• Furin encodes a protein or proteins that contain the following InterPro domains: Furin-like repeat, Galactose-binding domain-like, Growth factor, receptor, Peptidase S8, subtilisin, Asp-active site, Peptidase S8, subtilisin, His-active site, Peptidase S8, subtilisin, Ser-active site, Peptidase S8, subtilisin-related, Peptidase S8/S53, subtilisin/kexin/sedolisin, Proprotein convertase, P, Proteinase inhibitor, propeptide, indicating that the gene product:
  • participates in the following biological processes:
    • proteolysis

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Furin indicates that it:
  • participates in the following biological processes:
    • proteolysis
  • performs the following molecular functions:
    • hydrolase activity
    • metal ion binding
    • serine-type peptidase activity
  • is located in the following cellular components:
    • membrane

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References

1. Andersson O et al. (2007) Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol, 311:500-11. (PubMed:17936261)
2. Liu G et al. (1997) Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway. J Cell Biol, 139:1719-33. (PubMed:9412467)
3. Yang T et al. (2010) E-selectin ligand-1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-beta. J Clin Invest, 120:2474-85. (PubMed:20530870)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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