Automated description from the Alliance of Genome Resources (Release 3.2)
Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription cofactor binding activity; and chromatin binding activity. Involved in several processes, including animal organ development; nervous system development; and regulation of transcription by RNA polymerase II. Localizes to nucleus. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; nose; and urogenital sinus. Used to study Waardenburg syndrome type 1; alveolar rhabdomyosarcoma; and neural tube defect. Human ortholog(s) of this gene implicated in Waardenburg syndrome type 1; Waardenburg syndrome type 3; Waardenburg's syndrome; alveolar rhabdomyosarcoma; and craniofacial-deafness-hand syndrome. Orthologous to human PAX3 (paired box 3).