Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Oprm1. (This text reflects annotations as of Wednesday, January 23, 2013.)

---

Summary from NCBI RefSeq

This gene encodes the mu opioid receptor which is where drugs such as morphine and other opioids have pharmacological effects. Alternatively spliced transcript variants have been found for this gene, however, many of these variants may be NMD candidates. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Oprm1
  • participates in the following biological processes:
    • adenylate cyclase-activating dopamine receptor signaling pathway ^[4]
    • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ^[4]
  • performs the following molecular functions:
    • opioid receptor activity ^[4]
  • is located in the following cellular components:
    • membrane ^[4]
• The gene product of Oprm1 has been shown to bind to the gene products of Grpr. ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Oprm1
  • participates in the following biological processes:
    • behavior ^[1]
    • positive regulation of neurogenesis ^[5]
    • sensory perception of pain ^[6]
• Researchers have inferred, based on genetic interactions, that the gene product of Oprm1
  • participates in the following biological processes:
    • locomotory behavior based on interactions with Drd3 ^[3]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Oprm1:
  • participates in the following biological processes:
    • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
    • adenylate cyclase-inhibiting opioid receptor signaling pathway
    • behavioral response to ethanol
    • cellular response to stress
    • elevation of cytosolic calcium ion concentration
    • G-protein coupled receptor signaling pathway
    • negative regulation of cAMP-mediated signaling
    • negative regulation of nitric oxide biosynthetic process
    • negative regulation of Wnt protein secretion
    • positive regulation of appetite
    • positive regulation of cAMP-mediated signaling
    • positive regulation of nitric oxide biosynthetic process
    • reduction of cytosolic calcium ion concentration
    • regulation of behavior
    • regulation of excitatory postsynaptic membrane potential
    • regulation of sensory perception of pain
  • performs the following molecular functions:
    • beta-endorphin receptor activity
    • G-protein alpha-subunit binding
    • G-protein beta-subunit binding
    • G-protein coupled receptor activity
    • morphine receptor activity
  • is located in the following cellular components:
    • dendrite
    • dendrite cytoplasm
    • dendrite membrane
    • focal adhesion
    • intracellular part
    • membrane
    • membrane raft
    • perikaryon
    • sarcolemma

---

Summary text based on GO annotations supported by structural data

• Oprm1 encodes a protein or proteins that contain the following InterPro domains: GPCR, rhodopsin-like, GPCR, rhodopsin-like, 7TM, Mu opioid receptor, Opioid receptor, indicating that the gene product:
  • is located in the following cellular components:
    • integral to membrane

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Oprm1 indicates that it:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • plasma membrane

---

References

1. Filliol D et al. (2000) Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nat Genet, 25:195-200. (PubMed:10835636)
2. Liu XY et al. (2011) Unidirectional Cross-Activation of GRPR by MOR1D Uncouples Itch and Analgesia Induced by Opioids. Cell, 147:447-58. (PubMed:22000021)
3. Narita M et al. (2003) Molecular evidence for the functional role of dopamine D3 receptor in the morphine-induced rewarding effect and hyperlocomotion. J Neurosci, 23:1006-12. (PubMed:12574430)
4. Noble F et al. (1996) Differences among mouse strains in the regulation by mu, delta 1 and delta 2 opioid receptors of striatal adenylyl cyclases activated by dopamine D1 or adenosine A2a receptors. Brain Res, 716:107-17. (PubMed:8738226)
5. Rios C et al. (2006) mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis. Br J Pharmacol, 148:387-95. (PubMed:16682964)
6. Sora I et al. (1997) Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc Natl Acad Sci U S A, 94:1544-9. (PubMed:9037090)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---