Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Oprl1. (This text reflects annotations as of Thursday, January 16, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a G protein-coupled receptor whose expression can be induced by phytohemagglutinin. The encoded integral membrane protein is a receptor for the 17 aa neuropeptide nociceptin/orphanin FQ. This gene may be involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. A promoter for this gene also functions as a promoter for another gene, regulator of G-protein signalling 19 (RGS19), located on the opposite strand. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2011]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Oprl1
  • participates in the following biological processes:
    • opioid receptor signaling pathway ^[1]
    • sensory perception of pain ^[1]
  • performs the following molecular functions:
    • nociceptin receptor activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Oprl1:
  • participates in the following biological processes:
    • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
    • positive regulation of cytosolic calcium ion concentration
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • nociceptin receptor activity
  • is located in the following cellular components:
    • integral component of plasma membrane

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Summary text based on GO annotations supported by structural data

• Oprl1 encodes a protein or proteins that contain the following InterPro domains: G protein-coupled receptor, rhodopsin-like, GPCR, rhodopsin-like, 7TM, Opioid receptor, X opioid receptor, indicating that the gene product:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
  • performs the following molecular functions:
    • opioid receptor activity
  • is located in the following cellular components:
    • integral component of membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Oprl1 indicates that it:
  • participates in the following biological processes:
    • behavior
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • signal transducer activity
  • is located in the following cellular components:
    • cytoplasmic vesicle
    • integral component of membrane
    • membrane
    • plasma membrane

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References

1. Bertorelli R et al. (2002) Lack of the nociceptin receptor does not affect acute or chronic nociception in mice. Peptides, 23:1589-96. (PubMed:12217419)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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