Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Oprd1. (This text reflects annotations as of Wednesday, August 14, 2013.)

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Oprd1
  • participates in the following biological processes:
    • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway ^[3]
    • neuropeptide signaling pathway ^[4]
  • performs the following molecular functions:
    • opioid receptor activity ^{[3, 4]}
  • is located in the following cellular components:
    • integral to membrane ^[4]
    • membrane ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Oprd1
  • participates in the following biological processes:
    • adult locomotory behavior ^[1]
  • performs the following molecular functions:
    • opioid receptor activity ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Oprd1:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • opioid receptor signaling pathway
    • phospholipase C-activating G-protein coupled receptor signaling pathway
    • protein import into nucleus, translocation
    • regulation of calcium ion transport
    • regulation of sensory perception of pain
  • performs the following molecular functions:
    • enkephalin receptor activity
  • is located in the following cellular components:
    • axon terminus
    • cytoplasm
    • dendrite membrane
    • membrane raft
    • plasma membrane
    • postsynaptic membrane
    • vesicle

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Summary text based on GO annotations supported by structural data

• Oprd1 encodes a protein or proteins that contain the following InterPro domains: Delta opioid receptor, G protein-coupled receptor, rhodopsin-like, GPCR, rhodopsin-like, 7TM, Opioid receptor, indicating that the gene product:
  • performs the following molecular functions:
    • G-protein coupled receptor activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Oprd1 indicates that it:
  • participates in the following biological processes:
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity

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References

1. Filliol D et al. (2000) Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses. Nat Genet, 25:195-200. (PubMed:10835636)
2. Goody RJ et al. (2002) Quantitative autoradiographic mapping of opioid receptors in the brain of delta-opioid receptor gene knockout mice. Brain Res, 945:9-19. (PubMed:12113946)
3. Noble F et al. (1996) Differences among mouse strains in the regulation by mu, delta 1 and delta 2 opioid receptors of striatal adenylyl cyclases activated by dopamine D1 or adenosine A2a receptors. Brain Res, 716:107-17. (PubMed:8738226)
4. Yasuda K et al. (1993) Cloning and functional comparison of kappa and delta opioid receptors from mouse brain. Proc Natl Acad Sci U S A, 90:6736-40. (PubMed:8393575)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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