Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Odc1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Odc1
  • participates in the following biological processes:
    • metabolic process ^{[2, 3]}
  • performs the following molecular functions:
    • ornithine decarboxylase activity ^{[2, 3]}
  • is located in the following cellular components:
    • cytosol ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Odc1
  • participates in the following biological processes:
    • kidney development ^[1]
    • positive regulation of cell proliferation ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Odc1:
  • participates in the following biological processes:
    • polyamine metabolic process
    • putrescine biosynthetic process
  • performs the following molecular functions:
    • ornithine decarboxylase activity

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Summary text based on GO annotations supported by structural data

• Odc1 encodes a protein or proteins that contain the following InterPro domains: Alanine racemase/group IV decarboxylase, C-terminal, Orn/DAP/Arg decarboxylase 2, C-terminal, Orn/DAP/Arg decarboxylase 2, conserved site, Orn/DAP/Arg decarboxylase 2, N-terminal, Orn/DAP/Arg decarboxylase 2, pyridoxal-phosphate binding site, Ornithine decarboxylase, Ornithine/DAP/Arg decarboxylase, indicating that the gene product:
  • participates in the following biological processes:
    • polyamine biosynthetic process
  • performs the following molecular functions:
    • catalytic activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Odc1 indicates that it:
  • participates in the following biological processes:
    • polyamine biosynthetic process
  • performs the following molecular functions:
    • carboxy-lyase activity
    • lyase activity

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References

1. Loikkanen I et al. (2005) Polyamines are involved in murine kidney development controlling expression of c-ret, E-cadherin, and Pax2/8 genes. Differentiation, 73:303-12. (PubMed:16138831)
2. Lopez-Contreras AJ et al. (2006) Mouse ornithine decarboxylase-like gene encodes an antizyme inhibitor devoid of ornithine and arginine decarboxylating activity. J Biol Chem, 281:30896-906. (PubMed:16916800)
3. Tsirka SE et al. (1993) Multiple active conformers of mouse ornithine decarboxylase. Biochem J, 293:289-95. (PubMed:8328969)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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