Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ntf3. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ntf3
  • participates in the following biological processes:
    • axon guidance ^[8]
    • neuromuscular synaptic transmission ^[4]
    • positive regulation of transcription from RNA polymerase II promoter ^[11]
    • regulation of neuron apoptotic process ^[10]
  • is located in the following cellular components:
    • cytoplasmic membrane-bounded vesicle ^[13]
• The gene product of Ntf3 has been shown to bind to the gene products of Ngfr, Ntrk2. ^[5]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ntf3
  • participates in the following biological processes:
    • axon guidance ^{[8, 15]}
    • brain development ^[2]
    • enteric nervous system development ^[12]
    • epidermis development ^[3]
    • glial cell fate determination ^[9]
    • negative regulation of neuron apoptotic process ^[17]
    • nerve development ^[7]
    • neuron development ^[1]
    • peripheral nervous system development ^{[6, 11]}
    • smooth muscle cell differentiation ^[12]
• Researchers have inferred, based on genetic interactions, that the gene product of Ntf3
  • participates in the following biological processes:
    • generation of neurons based on interactions with Ntrk3 ^[16]
    • mechanoreceptor differentiation based on interactions with , ^[14]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ntf3:
  • participates in the following biological processes:
    • activation of MAPK activity
    • activation of protein kinase B activity
    • activation of Ras GTPase activity
    • induction of positive chemotaxis
    • myelination
    • negative regulation of peptidyl-tyrosine phosphorylation
    • nervous system development
    • positive chemotaxis
    • positive regulation of actin cytoskeleton reorganization
    • positive regulation of cell migration
    • positive regulation of cell proliferation
    • positive regulation of glial cell differentiation
    • positive regulation of peptidyl-serine phosphorylation
    • positive regulation of peptidyl-tyrosine phosphorylation
    • positive regulation of receptor internalization
    • regulation of synaptic transmission
    • transmembrane receptor protein tyrosine kinase signaling pathway
  • performs the following molecular functions:
    • chemoattractant activity
    • growth factor activity
    • nerve growth factor binding

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Summary text based on GO annotations supported by structural data

• Ntf3 encodes a protein or proteins that contain the following InterPro domains: Nerve growth factor conserved site, Nerve growth factor-like, Nerve growth factor-related, Neurotrophin-3, indicating that the gene product:
  • performs the following molecular functions:
    • neurotrophin receptor binding
    • receptor binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ntf3 indicates that it:
  • is located in the following cellular components:
    • extracellular region

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References

1. Airaksinen MS et al. (1996) Most classes of dorsal root ganglion neurons are severely depleted but not absent in mice lacking neurotrophin-3. Neuroscience, 73:907-11. (PubMed:8809809)
2. Bates B et al. (1999) Neurotrophin-3 is required for proper cerebellar development. Nat Neurosci, 2:115-7. (PubMed:10195193)
3. Botchkarev VA et al. (1998) A new role for neurotrophin-3: involvement in the regulation of hair follicle regression (catagen). Am J Pathol, 153:785-99. (PubMed:9736028)
4. Chen HH et al. (2002) Muscle spindle-derived neurotrophin 3 regulates synaptic connectivity between muscle sensory and motor neurons. J Neurosci, 22:3512-9. (PubMed:11978828)
5. Coppola V et al. (2001) Dissection of NT3 functions in vivo by gene replacement strategy. Development, 128:4315-27. (PubMed:11684666)
6. ElShamy WM et al. (1996) A local action of neurotrophin-3 prevents the death of proliferating sensory neuron precursor cells. Neuron, 16:963-72. (PubMed:8630254)
7. Ernfors P et al. (1995) Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron, 14:1153-64. (PubMed:7605630)
8. Genc B et al. (2004) A chemoattractant role for NT-3 in proprioceptive axon guidance. PLoS Biol, 2:e403. (PubMed:15550985)
9. Kahn MA et al. (1999) Mice lacking NT-3, and its receptor TrkC, exhibit profound deficiencies in CNS glial cells. Glia, 26:153-65. (PubMed:10384880)
10. Li HL et al. (2006) The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. FEBS Lett, 580:1723-8. (PubMed:16516892)
11. Patel TD et al. (2003) Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents. Neuron, 38:403-16. (PubMed:12741988)
12. Reddy T et al. (2004) Evidence for the involvement of neurotrophins in muscle transdifferentiation and acetylcholine receptor transformation in the esophagus of Myf5(-/-):MyoD(-/-) and NT-3(-/-) embryos. Dev Dyn, 231:683-92. (PubMed:15497153)
13. Sadakata T et al. (2004) The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J Neurosci, 24:43-52. (PubMed:14715936)
14. Sedy J et al. (2004) Pacinian corpuscle development involves multiple Trk signaling pathways. Dev Dyn, 231:551-63. (PubMed:15376326)
15. Staecker H et al. (1996) NGF, BDNF and NT-3 play unique roles in the in vitro development and patterning of innervation of the mammalian inner ear. Brain Res Dev Brain Res, 92:49-60. (PubMed:8861722)
16. Stenqvist A et al. (2005) Genetic evidence for selective neurotrophin 3 signalling through TrkC but not TrkB in vivo. EMBO Rep, 6:973-8. (PubMed:16142215)
17. Wu HH et al. (2009) Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor. Nat Neurosci, 12:1534-41. (PubMed:19915564)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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