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Gene Ontology Classifications
neurotrophin 3

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GO curators for mouse genes have assigned the following annotations to the gene product of Ntf3. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Airaksinen MS et al. (1996) Most classes of dorsal root ganglion neurons are severely depleted but not absent in mice lacking neurotrophin-3. Neuroscience, 73:907-11. (PubMed:8809809)
  2. Bates B et al. (1999) Neurotrophin-3 is required for proper cerebellar development. Nat Neurosci, 2:115-7. (PubMed:10195193)
  3. Botchkarev VA et al. (1998) A new role for neurotrophin-3: involvement in the regulation of hair follicle regression (catagen). Am J Pathol, 153:785-99. (PubMed:9736028)
  4. Chen HH et al. (2002) Muscle spindle-derived neurotrophin 3 regulates synaptic connectivity between muscle sensory and motor neurons. J Neurosci, 22:3512-9. (PubMed:11978828)
  5. Coppola V et al. (2001) Dissection of NT3 functions in vivo by gene replacement strategy. Development, 128:4315-27. (PubMed:11684666)
  6. ElShamy WM et al. (1996) A local action of neurotrophin-3 prevents the death of proliferating sensory neuron precursor cells. Neuron, 16:963-72. (PubMed:8630254)
  7. Ernfors P et al. (1995) Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron, 14:1153-64. (PubMed:7605630)
  8. Genc B et al. (2004) A chemoattractant role for NT-3 in proprioceptive axon guidance. PLoS Biol, 2:e403. (PubMed:15550985)
  9. Kahn MA et al. (1999) Mice lacking NT-3, and its receptor TrkC, exhibit profound deficiencies in CNS glial cells. Glia, 26:153-65. (PubMed:10384880)
  10. Li HL et al. (2006) The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. FEBS Lett, 580:1723-8. (PubMed:16516892)
  11. Patel TD et al. (2003) Peripheral NT3 signaling is required for ETS protein expression and central patterning of proprioceptive sensory afferents. Neuron, 38:403-16. (PubMed:12741988)
  12. Reddy T et al. (2004) Evidence for the involvement of neurotrophins in muscle transdifferentiation and acetylcholine receptor transformation in the esophagus of Myf5(-/-):MyoD(-/-) and NT-3(-/-) embryos. Dev Dyn, 231:683-92. (PubMed:15497153)
  13. Sadakata T et al. (2004) The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. J Neurosci, 24:43-52. (PubMed:14715936)
  14. Sedy J et al. (2004) Pacinian corpuscle development involves multiple Trk signaling pathways. Dev Dyn, 231:551-63. (PubMed:15376326)
  15. Staecker H et al. (1996) NGF, BDNF and NT-3 play unique roles in the in vitro development and patterning of innervation of the mammalian inner ear. Brain Res Dev Brain Res, 92:49-60. (PubMed:8861722)
  16. Stenqvist A et al. (2005) Genetic evidence for selective neurotrophin 3 signalling through TrkC but not TrkB in vivo. EMBO Rep, 6:973-8. (PubMed:16142215)
  17. Wu HH et al. (2009) Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor. Nat Neurosci, 12:1534-41. (PubMed:19915564)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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