Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ntf3. (This text reflects annotations as of Tuesday, July 8, 2014.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ntf3
  • participates in the following biological processes:
    • axon guidance ^[]
    • neuromuscular synaptic transmission ^[]
    • positive regulation of transcription from RNA polymerase II promoter ^[]
    • regulation of neuron apoptotic process ^[]
  • is located in the following cellular components:
    • cytoplasmic membrane-bounded vesicle ^[]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ntf3
  • participates in the following biological processes:
    • axon guidance ^{[, ]}
    • brain development ^[]
    • enteric nervous system development ^[]
    • epidermis development ^[]
    • glial cell fate determination ^[]
    • negative regulation of neuron apoptotic process ^[]
    • nerve development ^[]
    • neuron development ^[]
    • peripheral nervous system development ^{[, ]}
    • smooth muscle cell differentiation ^[]
• Researchers have inferred, based on genetic interactions, that the gene product of Ntf3
  • participates in the following biological processes:
    • generation of neurons based on interactions with Ntrk3 ^[]
    • mechanoreceptor differentiation based on interactions with , ^[]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ntf3:
  • participates in the following biological processes:
    • activation of MAPK activity
    • activation of protein kinase B activity
    • activation of Ras GTPase activity
    • induction of positive chemotaxis
    • myelination
    • negative regulation of peptidyl-tyrosine phosphorylation
    • nervous system development
    • positive chemotaxis
    • positive regulation of actin cytoskeleton reorganization
    • positive regulation of cell migration
    • positive regulation of cell proliferation
    • positive regulation of glial cell differentiation
    • positive regulation of peptidyl-serine phosphorylation
    • positive regulation of peptidyl-tyrosine phosphorylation
    • positive regulation of receptor internalization
    • regulation of synaptic transmission
    • transmembrane receptor protein tyrosine kinase signaling pathway
  • performs the following molecular functions:
    • chemoattractant activity
    • growth factor activity
    • nerve growth factor binding

---

Summary text based on GO annotations supported by structural data

• Ntf3 encodes a protein or proteins that contain the following InterPro domains: indicating that the gene product:
  • performs the following molecular functions:
    • neurotrophin receptor binding
    • receptor binding

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ntf3 indicates that it:
  • is located in the following cellular components:
    • extracellular region

---

References

1. . () , :. (PubMed:)
2. . () , :. (PubMed:)
3. . () , :. (PubMed:)
4. . () , :. (PubMed:)
5. . () , :. (PubMed:)
6. . () , :. (PubMed:)
7. . () , :. (PubMed:)
8. . () , :. (PubMed:)
9. . () , :. (PubMed:)
10. . () , :. (PubMed:)
11. . () , :. (PubMed:)
12. . () , :. (PubMed:)
13. . () , :. (PubMed:)
14. . () , :. (PubMed:)
15. . () , :. (PubMed:)
16. . () , :. (PubMed:)
17. . () , :. (PubMed:)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---