Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits several functions, including hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; metal ion binding activity; and phosphodiesterase I activity. Involved in several processes, including negative regulation of bone mineralization; negative regulation of fat cell differentiation; and negative regulation of hh target transcription factor activity. Localizes to cell surface; extracellular space; and integral component of plasma membrane. Is expressed in several structures, including central nervous system; integumental system; limb; sensory organ; and tooth. Used to study arterial calcification of infancy; bone disease (multiple); and middle ear disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1).