Automated description from the Alliance of Genome Resources
Exhibits several functions, including hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; metal ion binding activity; and phosphodiesterase I activity. Involved in several processes, including negative regulation of bone mineralization; negative regulation of fat cell differentiation; and negative regulation of hh target transcription factor activity. Localizes to the cell surface; extracellular space; and integral component of plasma membrane. Used to study arterial calcification of infancy; ossification of the posterior longitudinal ligament of spine; osteoarthritis; and spondyloarthropathy. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal failure; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1).