Automated description from the Alliance of Genome Resources (Release 4.1.0)
Enables several functions, including hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; metal ion binding activity; and phosphodiesterase I activity. Involved in several processes, including animal organ development; cell surface receptor signaling pathway; and neurogenesis. Acts upstream of or within bone remodeling and negative regulation of ossification. Located in cell surface and extracellular space. Is integral component of plasma membrane. Is expressed in several structures, including central nervous system; integumental system; limb; sensory organ; and tooth. Used to study arterial calcification of infancy; bone disease (multiple); and middle ear disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1).