Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nppa. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6. [provided by RefSeq, Sep 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Nppa
  • is located in the following cellular components:
    • cytoplasm ^[3]
    • extracellular space ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Nppa
  • participates in the following biological processes:
    • cardiac muscle hypertrophy in response to stress ^{[2, 4]}
    • female pregnancy ^[1]
    • regulation of blood pressure ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Nppa:
  • participates in the following biological processes:
    • cGMP biosynthetic process
    • negative regulation of cell growth
    • receptor guanylyl cyclase signaling pathway
    • regulation of blood pressure
  • performs the following molecular functions:
    • hormone activity
    • peptide hormone receptor binding
    • receptor binding
  • is located in the following cellular components:
    • cytoplasm
    • mast cell granule
    • nucleus
    • perinuclear region of cytoplasm

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Summary text based on GO annotations supported by structural data

• Nppa encodes a protein or proteins that contain the following InterPro domains: Natriuretic peptide, Natriuretic peptide, atrial type, indicating that the gene product:
  • is located in the following cellular components:
    • extracellular region

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Nppa indicates that it:
  • participates in the following biological processes:
    • regulation of blood vessel size
  • is located in the following cellular components:
    • extracellular region

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References

1. Cui Y et al. (2012) Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy. Nature, 484:246-50. (PubMed:22437503)
2. Franco V et al. (2004) Atrial natriuretic peptide dose-dependently inhibits pressure overload-induced cardiac remodeling. Hypertension, 44:746-50. (PubMed:15452027)
3. Iijima Y et al. (2003) Beating is necessary for transdifferentiation of skeletal muscle-derived cells into cardiomyocytes. FASEB J, 17:1361-3. (PubMed:12738802)
4. Mori T et al. (2004) Volume overload results in exaggerated cardiac hypertrophy in the atrial natriuretic peptide knockout mouse. Cardiovasc Res, 61:771-9. (PubMed:14985074)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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