Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables guanosine phosphorylase activity and purine-nucleoside phosphorylase activity. Involved in allantoin metabolic process; amide catabolic process; and nucleobase-containing small molecule metabolic process. Acts upstream of or within several processes, including nucleobase-containing small molecule metabolic process; positive regulation of lymphocyte activation; and urate biosynthetic process. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study purine nucleoside phosphorylase deficiency. Human ortholog(s) of this gene implicated in purine nucleoside phosphorylase deficiency and purine-pyrimidine metabolic disorder. Orthologous to human PNP (purine nucleoside phosphorylase).