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Gene Ontology Classifications
purine-nucleoside phosphorylase

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GO curators for mouse genes have assigned the following annotations to the gene product of Pnp. (This text reflects annotations as of Tuesday, May 26, 2015.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of April 29, 2008. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Arpaia E et al. (2000) Mitochondrial basis for immune deficiency. Evidence from purine nucleoside phosphorylase-deficient mice. J Exp Med, 191:2197-208. (PubMed:10859343)
  2. Blackburn MR et al. (1996) Metabolic and immunologic consequences of limited adenosine deaminase expression in mice. J Biol Chem, 271:15203-10. (PubMed:8663040)
  3. Bremner TA et al. (1978) Nucleoside phosphorylase 2 (Np-2) of mice. Biochem Genet, 16:1143-51. (PubMed:109081)
  4. Jenuth JP et al. (1991) Absence of dGTP accumulation and compensatory loss of deoxyguanosine kinase in purine nucleoside phosphorylase deficient mice. Adv Exp Med Biol, 309B:273-6. (PubMed:1664183)
  5. Kozak C et al. (1975) Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome. Somatic Cell Genet, 1:371-82. (PubMed:1235912)
  6. Kozak CA et al. (1977) Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids. Somatic Cell Genet, 3:121-33. (PubMed:204065)
  7. Lukey T et al. (1985) Purine nucleoside phosphorylase (Np) in the mouse: linkage relationship of Np-2 to esterase-10 (Es-10) and Np-1 on chromosome 14. Biochem Genet, 23:347-56. (PubMed:3925939)
  8. Mably ER et al. (1989) Genetic deficiency of purine nucleoside phosphorylase in the mouse. Characterization of partially and severely enzyme deficient mutants. Genome, 32:1026-32. (PubMed:2516826)
  9. Nelson DM et al. (1992) Isolation and expression of a murine purine nucleoside phosphorylase-encoding cDNA and sequence similarity with the human message. Gene, 113:215-21. (PubMed:1374046)
  10. Snyder FF. (1991) Genetic models of purine nucleoside phosphorylase deficiency in the mouse. Adv Exp Med Biol, 309B:137-40. (PubMed:1781357)
  11. Snyder FF et al. (1994) Secondary loss of deoxyguanosine kinase activity in purine nucleoside phosphorylase deficient mice. Biochim Biophys Acta, 1227:33-40. (PubMed:7918681)
  12. Snyder FF et al. (1983) Genetic variability of purine nucleoside phosphorylase activity in the mouse: relationship to Np-1 and Np-2. Biochem Genet, 21:323-32. (PubMed:6407470)
  13. Snyder FF et al. (1991) Rescue of a lethal purine nucleoside phosphorylase mutation in the mouse via a second locus interaction. Adv Exp Med Biol, 309B:133-6. (PubMed:1781356)
  14. Snyder FF et al. (1997) Point mutations at the purine nucleoside phosphorylase locus impair thymocyte differentiation in the mouse. Proc Natl Acad Sci U S A, 94:2522-7. (PubMed:9122228)
  15. Stallings RL et al. (1981) Confirmational, provisional, and/or regional assignment of 15 enzyme loci onto Chinese hamster autosomes 1, 2, and 7. Somatic Cell Genet, 7:683-98. (PubMed:7323947)
  16. Toro A et al. (2006) TAT-mediated intracellular delivery of purine nucleoside phosphorylase corrects its deficiency in mice. J Clin Invest, 116:2717-26. (PubMed:16964310)
  17. Womack JE et al. (1977) Mapping of nucleoside phosphorylase (Np-1) and esterase 10 (Es-10) on mouse chromosome 14. Biochem Genet, 15:347-55. (PubMed:405970)
  18. Yasue M et al. (1991) Chromosomal assignments of 23 biochemical loci of the rat by using rat x mouse somatic cell hybrids. Cytogenet Cell Genet, 57:142-8. (PubMed:1914521)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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