Automated description from the Alliance of Genome Resources
Exhibits nitric-oxide synthase activity and scaffold protein binding activity. Involved in several processes, including circulatory system development; negative regulation of muscle hyperplasia; and regulation of metal ion transport. Localizes to the cytoplasm and nucleus. Used to study aortic valve disease; essential hypertension; and persistent fetal circulation syndrome. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); eye disease (multiple); reproductive organ cancer (multiple); and vasculitis (multiple). Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human NOS3 (nitric oxide synthase 3).