Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nos3. (This text reflects annotations as of Tuesday, July 8, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Nos3
  • is located in the following cellular components:
    • cytoplasm ^[]
    • nucleus ^[]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Nos3
  • participates in the following biological processes:
    • angiogenesis ^[]
    • blood vessel remodeling ^[]
    • in utero embryonic development ^[]
    • lipopolysaccharide-mediated signaling pathway ^[]
    • lung development ^[]
    • negative regulation of calcium ion transport ^[]
    • negative regulation of cell proliferation ^[]
    • negative regulation of hydrolase activity ^[]
    • negative regulation of muscle hyperplasia ^[]
    • negative regulation of potassium ion transport ^[]
    • nitric oxide biosynthetic process ^[]
    • ovulation from ovarian follicle ^[]
    • oxidation-reduction process ^[]
    • positive regulation of angiogenesis ^[]
    • regulation of blood vessel size ^[]
    • regulation of sodium ion transport ^[]
    • smooth muscle hyperplasia ^[]
  • performs the following molecular functions:
    • nitric-oxide synthase activity ^[]
• Researchers have inferred, based on genetic interactions, that the gene product of Nos3
  • participates in the following biological processes:
    • regulation of the force of heart contraction by chemical signal based on interactions with Cav1 ^[]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Nos3:
  • participates in the following biological processes:
    • arginine catabolic process
    • cellular response to mechanical stimulus
    • cellular response to transforming growth factor beta stimulus
    • endothelial cell migration
    • negative regulation of blood pressure
    • negative regulation of smooth muscle cell proliferation
    • nitric oxide biosynthetic process
    • nitric oxide mediated signal transduction
    • positive regulation of apoptotic process
    • positive regulation of guanylate cyclase activity
    • positive regulation of vasodilation
    • regulation of systemic arterial blood pressure by endothelin
    • response to estradiol
    • signal transduction
  • performs the following molecular functions:
    • actin binding
    • actin monomer binding
    • arginine binding
    • beta-catenin binding
    • cadherin binding
    • calmodulin binding
    • heme binding
    • Hsp90 protein binding
    • NADPH-hemoprotein reductase activity
    • nitric-oxide synthase activity
    • nitric-oxide synthase binding
    • scaffold protein binding
    • tetrahydrobiopterin binding
  • is located in the following cellular components:
    • apical part of cell
    • caveola
    • cytoplasm
    • cytosol
    • Golgi apparatus
    • membrane raft
    • mitochondrion
    • nucleolus
    • nucleus
    • plasma membrane
    • sarcolemma
    • vesicle membrane

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Summary text based on GO annotations supported by structural data

• Nos3 encodes a protein or proteins that contain the following InterPro domains: indicating that the gene product:
  • performs the following molecular functions:
    • flavin adenine dinucleotide binding
    • FMN binding
    • iron ion binding
    • NADP binding
    • oxidoreductase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Nos3 indicates that it:
  • performs the following molecular functions:
    • metal ion binding
    • oxidoreductase activity
  • is located in the following cellular components:
    • cytoskeleton
    • membrane

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References

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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