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Gene Ontology Classifications
nitric oxide synthase 2, inducible

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GO curators for mouse genes have assigned the following annotations to the gene product of Nos2. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Ahn B et al. (2001) Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production. Cancer Res, 61:8357-60. (PubMed:11731407)
  2. Dai R et al. (2008) Suppression of LPS-induced Interferon-gamma and nitric oxide in splenic lymphocytes by select estrogen-regulated microRNAs: a novel mechanism of immune modulation. Blood, 112:4591-7. (PubMed:18791161)
  3. Daniliuc S et al. (2003) Hypoxia inactivates inducible nitric oxide synthase in mouse macrophages by disrupting its interaction with alpha-actinin 4. J Immunol, 171:3225-32. (PubMed:12960352)
  4. Degrandi D et al. (2007) Extensive characterization of IFN-induced GTPases mGBP1 to mGBP10 involved in host defense. J Immunol, 179:7729-40. (PubMed:18025219)
  5. Ghosh DK et al. (1997) Characterization of the inducible nitric oxide synthase oxygenase domain identifies a 49 amino acid segment required for subunit dimerization and tetrahydrobiopterin interaction. Biochemistry, 36:10609-19. (PubMed:9271491)
  6. Gyurko R et al. (2003) Mice lacking inducible nitric oxide synthase demonstrate impaired killing of Porphyromonas gingivalis. Infect Immun, 71:4917-24. (PubMed:12933833)
  7. Huang D et al. (2008) Nitric-oxide synthase 2 interacts with CD74 and inhibits its cleavage by caspase during dendritic cell development. J Biol Chem, 283:1713-22. (PubMed:18003616)
  8. Kim SF et al. (2005) Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2. Science, 310:1966-70. (PubMed:16373578)
  9. Li B et al. (2014) Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2. Biochem Biophys Res Commun, 444:555-61. (PubMed:24486487)
  10. Nishikimi A et al. (2001) Localization of nitric oxide synthase activity in unfertilized oocytes and fertilized embryos during preimplantation development in mice. Reproduction, 122:957-63. (PubMed:11732991)
  11. Niu S et al. (2011) The circadian deadenylase Nocturnin is necessary for stabilization of the iNOS mRNA in mice. PLoS One, 6:e26954. (PubMed:22073225)
  12. Scott DJ et al. (2001) Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the apc(min/+) mouse. Gastroenterology, 121:889-99. (PubMed:11606502)
  13. Stolz DB et al. (2002) Peroxisomal localization of inducible nitric oxide synthase in hepatocytes. Hepatology, 36:81-93. (PubMed:12085352)
  14. Stuehr DJ et al. (1992) Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical. J Biol Chem, 267:20547-50. (PubMed:1383204)
  15. Yoshida M et al. (2003) Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase. J Biol Chem, 278:36953-8. (PubMed:12855682)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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