About   Help   FAQ
Gene Ontology Classifications
Symbol
Name
ID
Nkx3-1
NK-3 transcription factor, locus 1 (Drosophila)
MGI:97352

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nkx3-1. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. Abdulkadir SA et al. (2002) Conditional loss of nkx3.1 in adult mice induces prostatic intraepithelial neoplasia. Mol Cell Biol, 22:1495-503. (PubMed:11839815)
  2. Bhatia-Gaur R et al. (1999) Roles for Nkx3.1 in prostate development and cancer. Genes Dev, 13:966-77. (PubMed:10215624)
  3. Carson JA et al. (2000) The smooth muscle gamma -actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor J Biol Chem, 275:39061-72. (PubMed:10993896)
  4. Gao N et al. (2005) Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation. Development, 132:3431-43. (PubMed:15987773)
  5. Muhlbradt E et al. (2009) NKX3.1 activates expression of insulin-like growth factor binding protein-3 to mediate insulin-like growth factor-I signaling and cell proliferation. Cancer Res, 69:2615-22. (PubMed:19258508)
  6. Schneider A et al. (2000) Targeted disruption of the nkx3.1 gene in mice results in morphogenetic defects of minor salivary glands: parallels to glandular duct morphogenesis in prostate Mech Dev, 95:163-74. (PubMed:10906459)
  7. Sciavolino PJ et al. (1997) Tissue-specific expression of murine Nkx3.1 in the male urogenital system. Dev Dyn, 209:127-38. (PubMed:9142502)
  8. Song H et al. (2009) Loss of Nkx3.1 leads to the activation of discrete downstream target genes during prostate tumorigenesis. Oncogene, 28:3307-19. (PubMed:19597465)
  9. Tanaka M et al. (2000) Nkx3.1, a murine homolog of drosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands Dev Dyn, 219:248-60. (PubMed:11002344)
  10. Wang X et al. (2008) Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development. Dev Dyn, 237:2963-2972. (PubMed:18816836)
  11. Zhang Y et al. (2008) Structural and functional analysis of domains mediating interaction between the bagpipe homologue, Nkx3.1 and serum response factor. Exp Biol Med (Maywood), 233:297-309. (PubMed:18296735)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory