Automated description from the Alliance of Genome Resources
Exhibits several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; protein dimerization activity; and serum response element binding activity. Involved in several processes, including circulatory system development; regulation of heart contraction; and regulation of transcription by RNA polymerase II. Localizes to the cytoplasm; nucleus; and transcription factor complex. Used to study atrial heart septal defect 7; congenital heart disease; hypoplastic left heart syndrome; and tetralogy of Fallot. Human ortholog(s) of this gene implicated in aortic valve disease 2; atrioventricular block; congenital heart disease (multiple); and congenital nongoitrous hypothyroidism 5. Orthologous to human NKX2-5 (NK2 homeobox 5).