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Gene Ontology Classifications
nerve growth factor

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ngf. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Bouschet T et al. (2003) Stimulation of the ERK Pathway by GTP-loaded Rap1 Requires the Concomitant Activation of Ras, Protein Kinase C, and Protein Kinase A in Neuronal Cells. J Biol Chem, 278:4778-85. (PubMed:12473665)
  2. Chen F et al. (1994) Cloning of a novel orphan receptor (GCNF) expressed during germ cell development. Mol Endocrinol, 8:1434-44. (PubMed:7854358)
  3. Chen M et al. (2012) Spatially coordinated kinase signaling regulates local axon degeneration. J Neurosci, 32:13439-53. (PubMed:23015435)
  4. Crowley C et al. (1994) Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell, 76:1001-11. (PubMed:8137419)
  5. Dieplinger B et al. (2007) The transcriptional corepressor TPA-inducible sequence 7 regulates adult axon growth through cellular retinoic acid binding protein II expression. Eur J Neurosci, 26:3358-67. (PubMed:18052984)
  6. Glebova NO et al. (2004) Heterogeneous requirement of NGF for sympathetic target innervation in vivo. J Neurosci, 24:743-51. (PubMed:14736860)
  7. Hingtgen CM et al. (2006) Stimulus-evoked release of neuropeptides is enhanced in sensory neurons from mice with a heterozygous mutation of the Nf1 gene. Neuroscience, 137:637-645. (PubMed:16298082)
  8. Jones A et al. (2013) Role of DNA methylation and epigenetic silencing of HAND2 in endometrial cancer development. PLoS Med, 10:e1001551. (PubMed:24265601)
  9. Kimura A et al. (2015) Valproic Acid Prevents NMDA-Induced Retinal Ganglion Cell Death via Stimulation of Neuronal TrkB Receptor Signaling. Am J Pathol, 185:756-64. (PubMed:25542970)
  10. Li HL et al. (2006) The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. FEBS Lett, 580:1723-8. (PubMed:16516892)
  11. Middleton G et al. (2001) Populations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis in the absence of NGF/TrkA signalling in vivo. Development, 128:4715-28. (PubMed:11731452)
  12. O'Donovan KJ et al. (2014) B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. J Exp Med, 211:801-14. (PubMed:24733831)
  13. Potts PR et al. (2003) Critical function of endogenous XIAP in regulating caspase activation during sympathetic neuronal apoptosis. J Cell Biol, 163:789-99. (PubMed:14623868)
  14. Staecker H et al. (1996) NGF, BDNF and NT-3 play unique roles in the in vitro development and patterning of innervation of the mammalian inner ear. Brain Res Dev Brain Res, 92:49-60. (PubMed:8861722)
  15. Suo D et al. (2014) Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival. Nat Neurosci, 17:36-45. (PubMed:24270184)
  16. Yu T et al. (2014) In vivo regulation of NGF-mediated functions by Nedd4-2 ubiquitination of TrkA. J Neurosci, 34:6098-106. (PubMed:24760869)

Go Annotations in Tabular Form (Text View) (GO Graph)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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