Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Ngf. (This text reflects annotations as of Tuesday, May 21, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Ngf
  • participates in the following biological processes:
    • regulation of neuron differentiation ^[5]
    • signal transduction ^[1]
  • performs the following molecular functions:
    • receptor signaling protein activity ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Ngf
  • participates in the following biological processes:
    • peripheral nervous system development ^[3]
    • positive regulation of axon extension ^[7]
    • sensory perception of pain ^[2]
• Researchers have inferred, based on genetic interactions, that the gene product of Ngf
  • participates in the following biological processes:
    • negative regulation of neuron apoptotic process based on interactions with Bax ^[6]
    • regulation of neurotransmitter secretion based on interactions with Nf1 ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Ngf:
  • participates in the following biological processes:
    • adult locomotory behavior
    • memory
    • negative regulation of type B pancreatic cell apoptotic process
    • neuron projection development
    • positive regulation of cell growth
    • positive regulation of cell proliferation
    • positive regulation of gene expression
    • positive regulation of neuron differentiation
    • positive regulation of neurotrophin TRK receptor signaling pathway
    • positive regulation of protein autophosphorylation
    • positive regulation of sequence-specific DNA binding transcription factor activity
    • positive regulation of stem cell proliferation
    • sensory perception of pain
  • performs the following molecular functions:
    • nerve growth factor receptor binding
  • is located in the following cellular components:
    • extracellular space

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Summary text based on GO annotations supported by structural data

• Ngf encodes a protein or proteins that contain the following InterPro domains: Nerve growth factor conserved site, Nerve growth factor, beta subunit, Nerve growth factor, beta subunit, mammalian, Nerve growth factor-like, Nerve growth factor-related, indicating that the gene product:
  • performs the following molecular functions:
    • receptor binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Ngf indicates that it:
  • performs the following molecular functions:
    • growth factor activity
  • is located in the following cellular components:
    • extracellular region

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References

1. Bouschet T et al. (2003) Stimulation of the ERK Pathway by GTP-loaded Rap1 Requires the Concomitant Activation of Ras, Protein Kinase C, and Protein Kinase A in Neuronal Cells. J Biol Chem, 278:4778-85. (PubMed:12473665)
2. Crowley C et al. (1994) Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell, 76:1001-11. (PubMed:8137419)
3. Glebova NO et al. (2004) Heterogeneous requirement of NGF for sympathetic target innervation in vivo. J Neurosci, 24:743-51. (PubMed:14736860)
4. Hingtgen CM et al. (2006) Stimulus-evoked release of neuropeptides is enhanced in sensory neurons from mice with a heterozygous mutation of the Nf1 gene. Neuroscience, 137:637-645. (PubMed:16298082)
5. Li HL et al. (2006) The novel neurotrophin-regulated neuronal development-associated protein, NDAP, mediates apoptosis. FEBS Lett, 580:1723-8. (PubMed:16516892)
6. Middleton G et al. (2001) Populations of NGF-dependent neurones differ in their requirement for BAX to undergo apoptosis in the absence of NGF/TrkA signalling in vivo. Development, 128:4715-28. (PubMed:11731452)
7. Staecker H et al. (1996) NGF, BDNF and NT-3 play unique roles in the in vitro development and patterning of innervation of the mammalian inner ear. Brain Res Dev Brain Res, 92:49-60. (PubMed:8861722)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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