Automated description from the Alliance of Genome Resources (Release 4.0)
Enables GTPase activator activity. Involved in negative regulation of fibroblast proliferation. Acts upstream of or within several processes, including animal organ development; modulation of chemical synaptic transmission; and nervous system development. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and integumental system. Used to study juvenile myelomonocytic leukemia and neurofibromatosis. Human ortholog(s) of this gene implicated in autistic disorder; hematologic cancer (multiple); nervous system cancer (multiple); neurofibromatosis 1; and neurofibromatosis-Noonan syndrome. Orthologous to human NF1 (neurofibromin 1).