Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Nat1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2). [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Nat1
  • participates in the following biological processes:
    • metabolic process ^[1]
  • performs the following molecular functions:
    • arylamine N-acetyltransferase activity ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Nat1:
  • performs the following molecular functions:
    • arylamine N-acetyltransferase activity
  • is located in the following cellular components:
    • cytosol

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Summary text based on GO annotations supported by structural data

• Nat1 encodes a protein or proteins that contain the following InterPro domains: Arylamine N-acetyltransferase, indicating that the gene product:
  • performs the following molecular functions:
    • acetyltransferase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Nat1 indicates that it:
  • performs the following molecular functions:
    • transferase activity
    • transferase activity, transferring acyl groups
  • is located in the following cellular components:
    • cytoplasm

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References

1. Kelly SL et al. (1994) Arylamine N-acetyltransferase in Balb/c mice: identification of a novel mouse isoenzyme by cloning and expression in vitro. Biochem J, 302:347-53. (PubMed:7545952)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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