Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and ubiquitin protein ligase binding activity. Involved in several processes, including NK T cell proliferation; positive regulation of metanephric cap mesenchymal cell proliferation; and positive regulation of transcription initiation by RNA polymerase II. Acts upstream of or within several processes, including cellular response to interferon-alpha; positive regulation of apoptotic process; and regulation of transcription by RNA polymerase II. Located in several cellular components, including nuclear body; perinuclear region of cytoplasm; and spindle. Part of Myc-Max complex and euchromatin. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; sensory organ; and urinary system. Used to study Burkitt lymphoma. Human ortholog(s) of this gene implicated in several diseases, including angiosarcoma; carcinoma (multiple); demyelinating disease; hematologic cancer (multiple); and prostate cancer (multiple). Orthologous to human MYC (MYC proto-oncogene, bHLH transcription factor).