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Gene Ontology Classifications
Symbol
Name
ID
Myb
myeloblastosis oncogene
MGI:97249

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Myb. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor that is a member of the MYB family of transcription factor genes. The protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional repression. This protein plays an essential role in the regulation of hematopoiesis and may play a role in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
References
  1. . () , :. (PubMed:)
  2. Afroze T et al. (2003) Calcineurin-independent regulation of plasma membrane Ca2+ ATPase-4 in the vascular smooth muscle cell cycle. Am J Physiol Cell Physiol, 285:C88-95. (PubMed:12660151)
  3. Favier D et al. (1994) Detection of proteins that bind to the leucine zipper motif of c-Myb. Oncogene, 9:305-11. (PubMed:8302594)
  4. Ferretti E et al. (2006) Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Mol Cell Biol, 26:5650-62. (PubMed:16847320)
  5. Kanei-Ishii C et al. (2004) Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK. Genes Dev, 18:816-29. (PubMed:15082531)
  6. Kurima K et al. (2011) A noncoding point mutation of zeb1 causes multiple developmental malformations and obesity in twirler mice. PLoS Genet, 7:e1002307. (PubMed:21980308)
  7. Matre V et al. (2003) The human neuroendocrine thyrotropin-releasing hormone receptor promoter is activated by the haematopoietic transcription factor c-Myb. Biochem J, 372:851-9. (PubMed:12628004)
  8. Park ES et al. (2007) Early embryonic lethality caused by targeted disruption of the TRAF-interacting protein (TRIP) gene. Biochem Biophys Res Commun, 363:971-7. (PubMed:17927961)
  9. Wu CX et al. (2004) Activation of mouse RAG-2 promoter by Myc-associated zinc finger protein. Biochem Biophys Res Commun, 317:1096-102. (PubMed:15094381)
  10. Zorbas M et al. (1999) c-Myb is critical for murine colon development. Oncogene, 18:5821-30. (PubMed:10523863)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory