Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Map2. (This text reflects annotations as of Thursday, July 24, 2014.)

---

Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]

---

Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Map2
  • participates in the following biological processes:
    • cellular response to organic substance ^[16]
  • performs the following molecular functions:
    • microtubule binding ^[10]
  • is located in the following cellular components:
    • cell body ^{[6, 13]}
    • cytoplasm ^[7]
    • dendrite ^{[1, 2, 6, 11, 12, 13, 15, 18, 20]}
    • dendritic shaft ^[17]
    • intracellular ^{[3, 14]}
    • neuron projection ^[4]
    • neuronal cell body ^{[4, 5, 19]}
    • nuclear periphery ^[12]
• The gene product of Map2 has been shown to bind to the gene products of Kndc1, Tpgs1. ^{[9, 10]}
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Map2
  • participates in the following biological processes:
    • axonogenesis ^[8]
    • dendrite development ^[21]
    • microtubule bundle formation ^[21]
• Researchers have inferred, based on genetic interactions, that the gene product of Map2
  • participates in the following biological processes:
    • axonogenesis based on interactions with Map1b ^[8]

---

Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Map2:
  • performs the following molecular functions:
    • dystroglycan binding
  • is located in the following cellular components:
    • dendrite
    • neuron projection
    • neuronal cell body
    • protein complex
    • rough endoplasmic reticulum
    • smooth endoplasmic reticulum

---

Summary text based on GO annotations supported by structural data

• Map2 encodes a protein or proteins that contain the following InterPro domains: MAP2/Tau projection, Microtubule associated protein MAP2/MAP4/Tau, RII binding domain, Tau and MAP proteins tubulin-binding repeat, indicating that the gene product:
  • performs the following molecular functions:
    • tubulin binding

---

Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Map2 indicates that it:
  • performs the following molecular functions:
    • calmodulin binding
  • is located in the following cellular components:
    • cytoskeleton
    • microtubule

---

References

1. Bretin S et al. (2005) Differential expression of CRMP1, CRMP2A, CRMP2B, and CRMP5 in axons or dendrites of distinct neurons in the mouse brain. J Comp Neurol, 486:1-17. (PubMed:15834957)
2. Brion JP et al. (1988) Dendritic and axonal distribution of the microtubule-associated proteins MAP2 and tau in the cerebellum of the nervous mutant mouse. Brain Res Dev Brain Res, 44:221-32. (PubMed:3147150)
3. Cappello S et al. (2006) The Rho-GTPase cdc42 regulates neural progenitor fate at the apical surface. Nat Neurosci, 9:1099-107. (PubMed:16892058)
4. Chen LM et al. (2008) Expression and localization of Na-driven Cl-HCO(3)(-) exchanger (SLC4A8) in rodent CNS. Neuroscience, 153:162-74. (PubMed:18359573)
5. Franke H et al. (2005) P2X(7) receptor-mRNA and -protein in the mouse retina; changes during retinal degeneration in BALBCrds mice. Neurochem Int, 47:235-42. (PubMed:15964665)
6. Fukami S et al. (2002) Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res, 43:39-56. (PubMed:12074840)
7. Gingras H et al. (2005) Biochemical characterization of the mammalian Cux2 protein. Gene, 344:273-85. (PubMed:15656993)
8. Gonzalez-Billault C et al. (2002) Participation of structural microtubule-associated proteins (MAPs) in the development of neuronal polarity. J Neurosci Res, 67:713-9. (PubMed:11891784)
9. Huang J et al. (2011) Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth--structure and function of the second kinase noncatalytic C-lobe domain. FEBS J, 278:1651-61. (PubMed:21385318)
10. Ikegami K et al. (2007) Loss of alpha-tubulin polyglutamylation in ROSA22 mice is associated with abnormal targeting of KIF1A and modulated synaptic function. Proc Natl Acad Sci U S A, 104:3213-8. (PubMed:17360631)
11. Kim S et al. (2006) NGL family PSD-95-interacting adhesion molecules regulate excitatory synapse formation. Nat Neurosci, 9:1294-301. (PubMed:16980967)
12. Kuramochi Y et al. (2002) Characterization of mouse homolog of brain acyl-CoA hydrolase: molecular cloning and neuronal localization. Brain Res Mol Brain Res, 98:81-92. (PubMed:11834298)
13. Kuvbachieva A et al. (2004) Identification of a novel brain-specific and Reelin-regulated gene that encodes a protein colocalized with synapsin. Eur J Neurosci, 20:603-10. (PubMed:15255972)
14. Mishra A et al. (2008) The protein dendrite arborization and synapse maturation 1 (Dasm-1) is dispensable for dendrite arborization. Mol Cell Biol, 28:2782-91. (PubMed:18268009)
15. Ouyang Q et al. (2013) Christianson Syndrome Protein NHE6 Modulates TrkB Endosomal Signaling Required for Neuronal Circuit Development. Neuron, 80:97-112. (PubMed:24035762)
16. Pickford F et al. (2008) The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice. J Clin Invest, 118:2190-9. (PubMed:18497889)
17. Ryan XP et al. (2005) The Rho-Specific GEF Lfc Interacts with Neurabin and Spinophilin to Regulate Dendritic Spine Morphology. Neuron, 47:85-100. (PubMed:15996550)
18. Sawallisch C et al. (2009) The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampal synaptic plasticity. J Biol Chem, 284:9225-36. (PubMed:19208628)
19. Smorodchenko A et al. (2009) Comparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during development. Biochim Biophys Acta, 1788:2309-19. (PubMed:19646951)
20. Stegeman S et al. (2013) Loss of Usp9x disrupts cortical architecture, hippocampal development and TGFbeta-mediated axonogenesis. PLoS One, 8:e68287. (PubMed:23861879)
21. Teng J et al. (2001) Synergistic effects of MAP2 and MAP1B knockout in neuronal migration, dendritic outgrowth, and microtubule organization. J Cell Biol, 155:65-76. (PubMed:11581286)

---

---

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

---