Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mpo. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of netrophils. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Mpo
  • participates in the following biological processes:
    • hydrogen peroxide catabolic process ^[2]
    • oxidation-reduction process ^{[1, 2, 3, 4]}
  • performs the following molecular functions:
    • peroxidase activity ^{[1, 2, 3, 4]}
  • is located in the following cellular components:
    • mitochondrion ^[5]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Mpo
  • participates in the following biological processes:
    • defense response to fungus ^[2]
    • hydrogen peroxide catabolic process ^[2]
    • hypochlorous acid biosynthetic process ^[2]
    • negative regulation of growth of symbiont in host ^[2]
    • oxidation-reduction process ^[2]
    • removal of superoxide radicals ^[2]
    • respiratory burst involved in defense response ^[2]
    • response to yeast ^[2]
  • performs the following molecular functions:
    • peroxidase activity ^[2]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Mpo:
  • participates in the following biological processes:
    • hydrogen peroxide catabolic process
    • low-density lipoprotein particle remodeling
    • oxidation-reduction process
    • response to oxidative stress
  • performs the following molecular functions:
    • heparin binding
    • peroxidase activity
  • is located in the following cellular components:
    • extracellular space
    • secretory granule

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Summary text based on GO annotations supported by structural data

• Mpo encodes a protein or proteins that contain the following InterPro domains: Haem peroxidase, Haem peroxidase, animal, Haem peroxidase, animal, subgroup, indicating that the gene product:
  • performs the following molecular functions:
    • heme binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mpo indicates that it:
  • performs the following molecular functions:
    • metal ion binding
    • oxidoreductase activity
  • is located in the following cellular components:
    • lysosome

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References

1. Anton PM et al. (2004) Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation. Proc Natl Acad Sci U S A, 101:8503-8. (PubMed:15159534)
2. Aratani Y et al. (1999) Severe impairment in early host defense against Candida albicans in mice deficient in myeloperoxidase. Infect Immun, 67:1828-36. (PubMed:10085024)
3. Dahl R et al. (2002) Spi-B can functionally replace PU.1 in myeloid but not lymphoid development. EMBO J, 21:2220-30. (PubMed:11980719)
4. Hogenboom S et al. (2002) Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis. J Lipid Res, 43:90-8. (PubMed:11792727)
5. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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