Automated description from the Alliance of Genome Resources
Predicted to have thrombopoietin receptor activity. Involved in several processes, including hemopoiesis; regulation of stem cell division; and thrombopoietin-mediated signaling pathway. Predicted to localize to several cellular components, including the Golgi apparatus; neuronal cell body; and nuclear membrane. Used to study congenital amegakaryocytic thrombocytopenia. Human ortholog(s) of this gene implicated in congenital amegakaryocytic thrombocytopenia; essential thrombocythemia; myelofibrosis; thrombocytopenia; and thrombocytosis. Is expressed in several structures, including dorsal aorta; hemolymphoid system; mesenchyme derived from splanchnopleure; reproductive system; and yolk sac. Orthologous to human MPL (MPL proto-oncogene, thrombopoietin receptor).