Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mmp9. (This text reflects annotations as of Thursday, January 16, 2014.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Mmp9
  • participates in the following biological processes:
    • collagen catabolic process ^[2]
    • embryo implantation ^[1]
  • performs the following molecular functions:
    • metalloendopeptidase activity ^{[2, 3, 5]}
    • peptidase activity ^[4]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Mmp9
  • participates in the following biological processes:
    • extracellular matrix organization ^[4]
    • positive regulation of apoptotic process ^[4]
    • skeletal system development ^[4]
• Researchers have inferred, based on genetic interactions, that the gene product of Mmp9
  • participates in the following biological processes:
    • extracellular matrix organization based on interactions with Lgals3 ^[4]
    • skeletal system development based on interactions with Lgals3 ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Mmp9:
  • participates in the following biological processes:
    • cellular response to cell-matrix adhesion
    • collagen catabolic process
    • positive regulation of angiogenesis
    • positive regulation of keratinocyte migration
    • positive regulation of leukocyte migration
    • positive regulation of synaptic plasticity
    • protein oligomerization
    • proteolysis
    • response to drug
    • response to oxidative stress
    • tissue remodeling
    • transformation of host cell by virus
  • performs the following molecular functions:
    • fibronectin binding
    • identical protein binding
    • metalloendopeptidase activity
    • metallopeptidase activity
    • peptidase activity
    • protein complex binding
  • is located in the following cellular components:
    • extracellular space
    • protein complex

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Summary text based on GO annotations supported by structural data

• Mmp9 encodes a protein or proteins that contain the following InterPro domains: Fibronectin, type II, collagen-binding, Hemopexin, conserved site, Hemopexin-like domain, Hemopexin-like repeats, Kringle-like fold, Metallopeptidase, catalytic domain, Peptidase M10, metallopeptidase, Peptidase M10A, Peptidase M10A, cysteine switch, zinc binding site, Peptidase, metallopeptidase, Peptidoglycan binding-like, PT repeat, indicating that the gene product:
  • performs the following molecular functions:
    • zinc ion binding
  • is located in the following cellular components:
    • extracellular matrix

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mmp9 indicates that it:
  • performs the following molecular functions:
    • hydrolase activity
    • metal ion binding
  • is located in the following cellular components:
    • extracellular region
    • proteinaceous extracellular matrix

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References

1. Hu SJ et al. (2008) MicroRNA expression and regulation in mouse uterus during embryo implantation. J Biol Chem, 283:23473-84. (PubMed:18556655)
2. Leco KJ et al. (1997) Matrix metalloproteinase-9 maps to the distal end of chromosome 2 in the mouse. Dev Genet, 21:55-60. (PubMed:9291580)
3. Minamitani T et al. (2002) Adhesive defect in extracellular matrix tenascin-X-null fibroblasts: a possible mechanism of tumor invasion. Biol Pharm Bull, 25:1472-5. (PubMed:12419962)
4. Ortega N et al. (2005) Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation. Mol Biol Cell, 16:3028-39. (PubMed:15800063)
5. Webb DC et al. (2004) Polymorphisms in IL-4R alpha correlate with airways hyperreactivity, eosinophilia, and Ym protein expression in allergic IL-13-/- mice. J Immunol, 172:1092-8. (PubMed:14707083)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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