Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Mme. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Mme
  • participates in the following biological processes:
    • beta-amyloid metabolic process ^[2]
  • performs the following molecular functions:
    • peptidase activity ^[3]
  • is located in the following cellular components:
    • axon ^[2]
    • dendrite ^[2]
    • membrane ^[3]
    • neuron projection terminus ^[2]
    • synapse ^[2]
    • synaptic vesicle ^[2]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Mme
  • participates in the following biological processes:
    • sensory perception of pain ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Mme:
  • participates in the following biological processes:
    • cellular response to cytokine stimulus
    • cellular response to UV-A
    • cellular response to UV-B
    • creatinine metabolic process
    • peptide metabolic process
    • proteolysis
  • performs the following molecular functions:
    • endopeptidase activity
    • metalloendopeptidase activity
    • peptide binding
    • zinc ion binding
  • is located in the following cellular components:
    • brush border
    • cytoplasm
    • membrane
    • plasma membrane

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Summary text based on GO annotations supported by structural data

• Mme encodes a protein or proteins that contain the following InterPro domains: Metallopeptidase, catalytic domain, Peptidase M13, Peptidase M13, neprilysin, Peptidase M13, neprilysin, C-terminal, indicating that the gene product:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • metallopeptidase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Mme indicates that it:
  • participates in the following biological processes:
    • metabolic process
  • performs the following molecular functions:
    • hydrolase activity
    • metal ion binding
    • metallopeptidase activity
  • is located in the following cellular components:
    • integral to membrane

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References

1. Chen H et al. (1998) Aminophosphinic inhibitors as transition state analogues of enkephalin-degrading enzymes: a class of central analgesics. Proc Natl Acad Sci U S A, 95:12028-33. (PubMed:9751784)
2. Fukami S et al. (2002) Abeta-degrading endopeptidase, neprilysin, in mouse brain: synaptic and axonal localization inversely correlating with Abeta pathology. Neurosci Res, 43:39-56. (PubMed:12074840)
3. Pardossi-Piquard R et al. (2005) Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron, 46:541-54. (PubMed:15944124)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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