Automated description from the Alliance of Genome Resources
Exhibits RNA polymerase II distal enhancer sequence-specific DNA binding activity and chromatin binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; macromolecule methylation; and regulation of histone modification. Localizes to the nucleus. Used to study acute lymphocytic leukemia and acute myeloid leukemia. Human ortholog(s) of this gene implicated in B- and T-cell mixed leukemia; acute myeloid leukemia; cervical cancer; and non-Hodgkin lymphoma. Is expressed in several structures, including extraembryonic component; genitourinary system; hematopoietic system; nervous system; and retina. Orthologous to human KMT2A (lysine methyltransferase 2A).