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Gene Ontology Classifications
met proto-oncogene

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GO curators for mouse genes have assigned the following annotations to the gene product of Met. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text based on GO annotations supported by structural data
Summary text for additional MGI annotations
  1. Artigiani S et al. (2004) Plexin-B3 is a functional receptor for semaphorin 5A. EMBO Rep, 5:710-4. (PubMed:15218527)
  2. Bladt F et al. (1995) Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud [see comments] Nature, 376:768-71. (PubMed:7651534)
  3. Dai C et al. (2005) {beta}-Cell-Specific Ablation of the Hepatocyte Growth Factor Receptor Results in Reduced Islet Size, Impaired Insulin Secretion, and Glucose Intolerance. Am J Pathol, 167:429-36. (PubMed:16049329)
  4. Higuchi T et al. (2004) MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met. Mol Cell Biol, 24:7456-68. (PubMed:15314156)
  5. Ieraci A et al. (2002) Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development. Proc Natl Acad Sci U S A, 99:15200-5. (PubMed:12397180)
  6. Ikari T et al. (2003) Involvement of hepatocyte growth factor in branching morphogenesis of murine salivary gland. Dev Dyn, 228:173-84. (PubMed:14517989)
  7. Komada M et al. (1995) Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain. Mol Cell Biol, 15:6213-21. (PubMed:7565774)
  8. Leiser D et al. (2014) Targeting of the MET receptor tyrosine kinase by small molecule inhibitors leads to MET accumulation by impairing the receptor downregulation. FEBS Lett, 588:653-8. (PubMed:24440350)
  9. Lu KV et al. (2012) VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex. Cancer Cell, 22:21-35. (PubMed:22789536)
  10. Ly A et al. (2008) DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. Cell, 133:1241-54. (PubMed:18585357)
  11. Ponzetto C et al. (2000) Met signaling mutants as tools for developmental studies. Int J Dev Biol, 44:645-53. (PubMed:11061428)
  12. Prunotto C et al. (2004) Analysis of Mlc-lacZ Met mutants highlights the essential function of Met for migratory precursors of hypaxial muscles and reveals a role for Met in the development of hyoid arch-derived facial muscles. Dev Dyn, 231:582-91. (PubMed:15376315)
  13. Qiu S et al. (2011) Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated met receptor tyrosine kinase. J Neurosci, 31:5855-64. (PubMed:21490227)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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