Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Met. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Met
  • participates in the following biological processes:
    • hepatocyte growth factor receptor signaling pathway ^[3]
    • protein autophosphorylation ^[3]
  • performs the following molecular functions:
    • hepatocyte growth factor-activated receptor activity ^[3]
    • protein kinase activity ^[1]
  • is located in the following cellular components:
    • membrane ^[6]
• The gene product of Met has been shown to bind to the gene products of Kdr. ^{[7, 8]} Researchers have inferred, based on physical interactions, that the gene product of Met
  • participates in the following biological processes:
    • activation of MAPK activity ^[3]
  • performs the following molecular functions:
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Met
  • participates in the following biological processes:
    • adult behavior ^[4]
    • brain development ^[4]
    • glucose homeostasis ^[2]
    • liver development ^[1]
    • muscle cell migration ^[1]
    • muscle organ development ^[10]
    • myoblast proliferation ^[9]
    • myotube differentiation ^[1]
    • placenta development ^[1]
    • positive regulation of glucose transport ^[2]
    • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling ^[5]
    • regulation of excitatory postsynaptic membrane potential ^[11]
    • regulation of synaptic transmission ^[11]
    • skeletal muscle tissue development ^[1]
• Researchers have inferred, based on genetic interactions, that the gene product of Met
  • participates in the following biological processes:
    • muscle organ development based on interactions with Pax3 ^[10]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Met:
  • participates in the following biological processes:
    • branching morphogenesis of a tube
    • negative regulation of hydrogen peroxide-mediated programmed cell death
    • negative regulation of peptidyl-threonine phosphorylation
    • negative regulation of transcription from RNA polymerase II promoter
    • neuron migration
    • positive regulation of dendrite morphogenesis
    • positive regulation of DNA replication
    • positive regulation of gene expression
    • positive regulation of mitosis
    • positive regulation of neuron projection development
    • positive regulation of peptidyl-serine phosphorylation
    • positive regulation of peptidyl-threonine phosphorylation
    • positive regulation of transcription from RNA polymerase II promoter
    • protein autophosphorylation
    • sperm motility
  • performs the following molecular functions:
    • beta-catenin binding
    • hepatocyte growth factor-activated receptor activity
    • phosphatidylinositol 3-kinase binding
    • phospholipase binding
    • protein complex binding
    • protein heterodimerization activity
    • protein tyrosine kinase activity
  • is located in the following cellular components:
    • basal plasma membrane
    • cytoplasm
    • dendrite
    • excitatory synapse
    • extracellular space
    • flagellum
    • neuron projection
    • neuronal cell body
    • plasma membrane
    • postsynaptic density
    • postsynaptic membrane

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Summary text based on GO annotations supported by structural data

• Met encodes a protein or proteins that contain the following InterPro domains: Cell surface receptor IPT/TIG, Immunoglobulin E-set, Immunoglobulin-like fold, Plexin, Plexin-like fold, Plexin/semaphorin/integrin, Protein kinase, ATP binding site, Protein kinase, catalytic domain, Protein kinase-like domain, Semaphorin/CD100 antigen, Serine-threonine/tyrosine-protein kinase catalytic domain, Tyrosine-protein kinase, active site, Tyrosine-protein kinase, catalytic domain, Tyrosine-protein kinase, HGF/MSP receptor, WD40/YVTN repeat-like-containing domain, indicating that the gene product:
  • participates in the following biological processes:
    • multicellular organismal development
    • protein phosphorylation
    • transmembrane receptor protein tyrosine kinase signaling pathway
  • performs the following molecular functions:
    • ATP binding
    • receptor activity
    • transferase activity, transferring phosphorus-containing groups
    • transmembrane receptor protein tyrosine kinase activity
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Met indicates that it:
  • participates in the following biological processes:
    • phosphorylation
  • performs the following molecular functions:
    • ATP binding
    • kinase activity
    • nucleotide binding
    • transferase activity
  • is located in the following cellular components:
    • integral to membrane
• Met has been associated with the Enzyme Commission numbers: 2.7.10.1, which implies that the gene product:
  • performs the following molecular functions:
    • transmembrane receptor protein tyrosine kinase activity

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References

1. Bladt F et al. (1995) Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud [see comments] Nature, 376:768-71. (PubMed:7651534)
2. Dai C et al. (2005) {beta}-Cell-Specific Ablation of the Hepatocyte Growth Factor Receptor Results in Reduced Islet Size, Impaired Insulin Secretion, and Glucose Intolerance. Am J Pathol, 167:429-36. (PubMed:16049329)
3. Higuchi T et al. (2004) MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met. Mol Cell Biol, 24:7456-68. (PubMed:15314156)
4. Ieraci A et al. (2002) Viable hypomorphic signaling mutant of the Met receptor reveals a role for hepatocyte growth factor in postnatal cerebellar development. Proc Natl Acad Sci U S A, 99:15200-5. (PubMed:12397180)
5. Ikari T et al. (2003) Involvement of hepatocyte growth factor in branching morphogenesis of murine salivary gland. Dev Dyn, 228:173-84. (PubMed:14517989)
6. Komada M et al. (1995) Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain. Mol Cell Biol, 15:6213-21. (PubMed:7565774)
7. Lu KV et al. (2012) VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex. Cancer Cell, 22:21-35. (PubMed:22789536)
8. Ly A et al. (2008) DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1. Cell, 133:1241-54. (PubMed:18585357)
9. Ponzetto C et al. (2000) Met signaling mutants as tools for developmental studies. Int J Dev Biol, 44:645-53. (PubMed:11061428)
10. Prunotto C et al. (2004) Analysis of Mlc-lacZ Met mutants highlights the essential function of Met for migratory precursors of hypaxial muscles and reveals a role for Met in the development of hyoid arch-derived facial muscles. Dev Dyn, 231:582-91. (PubMed:15376315)
11. Qiu S et al. (2011) Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated met receptor tyrosine kinase. J Neurosci, 31:5855-64. (PubMed:21490227)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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