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Gene Ontology Classifications
transformed mouse 3T3 cell double minute 2

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GO curators for mouse genes have assigned the following annotations to the gene product of Mdm2. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Bernardi R et al. (2004) PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat Cell Biol, 6:665-72. (PubMed:15195100)
  2. Bothner B et al. (2001) Defining the molecular basis of arf and hdm2 interactions. J Mol Biol, 314:263-77. (PubMed:11718560)
  3. Boyd MT et al. (2000) A novel cellular protein (MTBP) binds to MDM2 and induces a G1 arrest that is suppressed by MDM2. J Biol Chem, 275:31883-90. (PubMed:10906133)
  4. Brady SN et al. (2004) ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway. Mol Cell Biol, 24:9327-38. (PubMed:15485902)
  5. Bywater MJ et al. (2012) Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53. Cancer Cell, 22:51-65. (PubMed:22789538)
  6. Chiu SY et al. (2008) SUMO-specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages. PLoS Biol, 6:e310. (PubMed:19090619)
  7. Dias SS et al. (2009) Polo-like kinase-1 phosphorylates MDM2 at Ser260 and stimulates MDM2-mediated p53 turnover. FEBS Lett, 583:3543-8. (PubMed:19833129)
  8. Giglio S et al. (2010) Regulation of MDM4 (MDMX) function by p76(MDM2): a new facet in the control of p53 activity. Oncogene, 29:5935-45. (PubMed:20697359)
  9. Hasan MK et al. (2002) CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. J Biol Chem, 277:37765-70. (PubMed:12154087)
  10. Itahana K et al. (2007) Targeted Inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell, 12:355-66. (PubMed:17936560)
  11. Lai KP et al. (2010) S6K1 is a multifaceted regulator of Mdm2 that connects nutrient status and DNA damage response. EMBO J, 29:2994-3006. (PubMed:20657550)
  12. Lee D et al. (2012) Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1. EMBO Rep, 13:163-9. (PubMed:22173032)
  13. Lee JH et al. (2007) Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. J Cell Sci, 120:2259-71. (PubMed:17591690)
  14. Li X et al. (2009) Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5. J Biol Chem, 284:16170-82. (PubMed:19372219)
  15. Lin HK et al. (2002) Phosphorylation-dependent ubiquitylation and degradation of androgen receptor by Akt require Mdm2 E3 ligase. EMBO J, 21:4037-48. (PubMed:12145204)
  16. Liu D et al. (2010) Puma is required for p53-induced depletion of adult stem cells. Nat Cell Biol, 12:993-8. (PubMed:20818388)
  17. Macias E et al. (2010) An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction. Cancer Cell, 18:231-43. (PubMed:20832751)
  18. Masuhara M et al. (2003) Enhanced degradation of MDM2 by a nuclear envelope component, mouse germ cell-less. Biochem Biophys Res Commun, 308:927-32. (PubMed:12927808)
  19. Mekhail K et al. (2005) Regulation of ubiquitin ligase dynamics by the nucleolus. J Cell Biol, 170:733-44. (PubMed:16129783)
  20. Mesaeli N et al. (2004) Impaired p53 expression, function, and nuclear localization in calreticulin-deficient cells. Mol Biol Cell, 15:1862-70. (PubMed:14767071)
  21. Papin J et al. (2004) Bioinformatics and cellular signaling. Curr Opin Biotechnol, 15:78-81. (PubMed:15102471)
  22. Ross AP et al. (2013) A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting. PLoS One, 8:e69333. (PubMed:23935987)
  23. Saito A et al. (2005) Modulation of p53 degradation via MDM2-mediated ubiquitylation and the ubiquitin-proteasome system during reperfusion after stroke: role of oxidative stress. J Cereb Blood Flow Metab, 25:267-80. (PubMed:15678128)
  24. Tollini LA et al. (2014) Regulation of p53 by Mdm2 E3 ligase function is dispensable in embryogenesis and development, but essential in response to DNA damage. Cancer Cell, 26:235-47. (PubMed:25117711)
  25. Tsai NP et al. (2012) Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95. Cell, 151:1581-94. (PubMed:23260144)
  26. Yuan X et al. (2005) Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis. Mol Cell, 19:77-87. (PubMed:15989966)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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