Automated description from the Alliance of Genome Resources
Exhibits p53 binding activity; scaffold protein binding activity; and ubiquitin protein ligase activity. Involved in several processes, including blood vessel remodeling; circulatory system development; and traversing start control point of mitotic cell cycle. Localizes to the cytoplasm and nucleolus. Predicted to colocalize with the nuclear body. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma multiforme; ichthyosis; and sarcoma. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; respiratory system; and sensory organ. Orthologous to human MDM2 (MDM2 proto-oncogene).