Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Maoa. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Maoa
  • participates in the following biological processes:
    • dopamine catabolic process ^[1]
  • is located in the following cellular components:
    • mitochondrion ^{[2, 3]}

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Maoa:
  • participates in the following biological processes:
    • oxidation-reduction process
    • phenylethylamine metabolic process
    • serotonin metabolic process
  • performs the following molecular functions:
    • flavin adenine dinucleotide binding
    • primary amine oxidase activity
    • serotonin binding
  • is located in the following cellular components:
    • mitochondrial outer membrane

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Summary text based on GO annotations supported by structural data

• Maoa encodes a protein or proteins that contain the following InterPro domains: Amine oxidase, Flavin amine oxidase, indicating that the gene product:
  • performs the following molecular functions:
    • oxidoreductase activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Maoa indicates that it:
  • participates in the following biological processes:
    • catecholamine metabolic process
    • neurotransmitter catabolic process
  • performs the following molecular functions:
    • oxidoreductase activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Jones SR et al. (1998) Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc Natl Acad Sci U S A, 95:4029-34. (PubMed:9520487)
2. Mootha VK et al. (2003) Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Cell, 115:629-40. (PubMed:14651853)
3. Pagliarini DJ et al. (2008) A mitochondrial protein compendium elucidates complex I disease biology. Cell, 134:112-23. (PubMed:18614015)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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