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Gene Ontology Classifications
Symbol
Name
ID
Maf
avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog
MGI:96909

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Maf. (This text reflects annotations as of Thursday, July 24, 2014.)
Summary from NCBI RefSeq


[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
References
  1. Bettelli E et al. (2005) Foxp3 interacts with nuclear factor of activated T cells and NF-{kappa}B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A, 102:5138-43. (PubMed:15790681)
  2. DePianto DJ et al. (2003) Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice. Mol Vis, 9:288-94. (PubMed:12835653)
  3. Huang W et al. (2002) A New Long Form of c-Maf Cooperates with Sox9 to Activate the Type II Collagen Gene. J Biol Chem, 277:50668-75. (PubMed:12381733)
  4. Imaki J et al. (2004) Developmental contribution of c-maf in the kidney: distribution and developmental study of c-maf mRNA in normal mice kidney and histological study of c-maf knockout mice kidney and liver. Biochem Biophys Res Commun, 320:1323-7. (PubMed:15249232)
  5. Kawauchi S et al. (1999) Regulation of lens fiber cell differentiation by transcription factor c-Maf. J Biol Chem, 274:19254-60. (PubMed:10383433)
  6. Kim JI et al. (1999) The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. Immunity, 10:745-51. (PubMed:10403649)
  7. Lu CC et al. (2011) Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J Neurosci, 31:10903-18. (PubMed:21795542)
  8. MacLean HE et al. (2003) Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development. Dev Biol, 262:51-63. (PubMed:14512017)
  9. Maeda A et al. (2009) Transcription factor GATA-3 is essential for lens development. Dev Dyn, 238:2280-2291. (PubMed:19623612)
  10. Mayo JL et al. (2009) The transcription factor Lc-Maf participates in Col27a1 regulation during chondrocyte maturation. Exp Cell Res, 315:2293-300. (PubMed:19414009)
  11. Motomura Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol, 12:450-9. (PubMed:21460847)
  12. Ring BZ et al. (2000) Regulation of mouse lens fiber cell development and differentiation by the Maf gene. Development, 127:307-17. (PubMed:10603348)
  13. Yang Y et al. (2006) Regulation of alphaA-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin. EMBO J, 25:2107-18. (PubMed:16675956)



Go Annotations in Tabular Form (Text View) (GO Graph)

 
 


Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory