Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Maf. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Maf
  • participates in the following biological processes:
    • cytokine production ^[1]
    • inner ear development ^[7]
    • positive regulation of gene expression ^[10]
    • positive regulation of transcription from RNA polymerase II promoter ^{[2, 3]}
  • performs the following molecular functions:
    • DNA binding ^[3]
    • sequence-specific DNA binding ^[11]
    • sequence-specific DNA binding transcription factor activity ^[2]
  • is located in the following cellular components:
    • cytoplasm ^[4]
    • nucleus ^[4]
• The gene product of Maf has been shown to bind to the gene products of Sox9. ^[3]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Maf
  • participates in the following biological processes:
    • cell development ^[11]
    • lens development in camera-type eye ^{[2, 5, 11]}
    • lens fiber cell differentiation ^{[2, 5]}
    • negative regulation of transcription from RNA polymerase II promoter ^[9]
    • positive regulation of transcription from RNA polymerase II promoter ^[11]
    • regulation of chondrocyte differentiation ^[8]
    • regulation of transcription, DNA-dependent ^[6]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Maf:
  • participates in the following biological processes:
    • positive regulation of transcription from RNA polymerase II promoter
    • transcription from RNA polymerase II promoter
  • performs the following molecular functions:
    • double-stranded DNA binding
    • protein heterodimerization activity
    • protein homodimerization activity
    • sequence-specific DNA binding RNA polymerase II transcription factor activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Maf indicates that it:
  • participates in the following biological processes:
    • transcription, DNA-dependent

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References

1. Bettelli E et al. (2005) Foxp3 interacts with nuclear factor of activated T cells and NF-{kappa}B to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A, 102:5138-43. (PubMed:15790681)
2. DePianto DJ et al. (2003) Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice. Mol Vis, 9:288-94. (PubMed:12835653)
3. Huang W et al. (2002) A New Long Form of c-Maf Cooperates with Sox9 to Activate the Type II Collagen Gene. J Biol Chem, 277:50668-75. (PubMed:12381733)
4. Imaki J et al. (2004) Developmental contribution of c-maf in the kidney: distribution and developmental study of c-maf mRNA in normal mice kidney and histological study of c-maf knockout mice kidney and liver. Biochem Biophys Res Commun, 320:1323-7. (PubMed:15249232)
5. Kawauchi S et al. (1999) Regulation of lens fiber cell differentiation by transcription factor c-Maf. J Biol Chem, 274:19254-60. (PubMed:10383433)
6. Kim JI et al. (1999) The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. Immunity, 10:745-51. (PubMed:10403649)
7. Lu CC et al. (2011) Developmental profiling of spiral ganglion neurons reveals insights into auditory circuit assembly. J Neurosci, 31:10903-18. (PubMed:21795542)
8. MacLean HE et al. (2003) Absence of transcription factor c-maf causes abnormal terminal differentiation of hypertrophic chondrocytes during endochondral bone development. Dev Biol, 262:51-63. (PubMed:14512017)
9. Maeda A et al. (2009) Transcription factor GATA-3 is essential for lens development. Dev Dyn, 238:2280-2291. (PubMed:19623612)
10. Motomura Y et al. (2011) The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat Immunol, 12:450-9. (PubMed:21460847)
11. Ring BZ et al. (2000) Regulation of mouse lens fiber cell development and differentiation by the Maf gene. Development, 127:307-17. (PubMed:10603348)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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