Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Alad. (This text reflects annotations as of Wednesday, January 23, 2013.) MGI curation of this mouse gene is considered complete, including annotations derived from the biomedical literature as of March 13, 2009. If you know of any additional information regarding this mouse gene please let us know. Please supply mouse gene symbol and a PubMed ID.

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Alad
  • participates in the following biological processes:
    • cellular response to interleukin-4 ^[1]
    • heme biosynthetic process ^{[2, 3, 4]}
  • performs the following molecular functions:
    • porphobilinogen synthase activity ^{[2, 3, 4]}
• Researchers have inferred, based on physical interactions, that the gene product of Alad
  • performs the following molecular functions:
    • identical protein binding ^[5]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Alad:
  • participates in the following biological processes:
    • heme biosynthetic process
    • protein homooligomerization
    • response to arsenic-containing substance
    • response to cadmium ion
    • response to chemical stimulus
    • response to drug
    • response to ethanol
    • response to metal ion
    • response to nutrient
    • response to organic substance
    • response to zinc ion
  • performs the following molecular functions:
    • identical protein binding
    • lead ion binding
    • porphobilinogen synthase activity
    • zinc ion binding
  • is located in the following cellular components:
    • cytosol
    • extracellular space

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Summary text based on GO annotations supported by structural data

• Alad encodes a protein or proteins that contain the following InterPro domains: Aldolase-type TIM barrel, Porphobilinogen synthase, indicating that the gene product:
  • participates in the following biological processes:
    • tetrapyrrole biosynthetic process
  • performs the following molecular functions:
    • catalytic activity
    • metal ion binding

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Alad indicates that it:
  • participates in the following biological processes:
    • metabolic process
    • porphyrin-containing compound biosynthetic process
  • performs the following molecular functions:
    • catalytic activity
    • lyase activity
    • metal ion binding

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References

1. Chu CC et al. (1998) Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol, 35:487-502. (PubMed:9798653)
2. Coleman DL. (1966) Purification and properties of delta-aminolevulinate dehydratase from tissues of two strains of mice. J Biol Chem, 241:5511-7. (PubMed:4959158)
3. Doyle D et al. (1969) The genetic and developmental regulation of hepatic delta-aminolevulinate dehydratase in mice. J Biol Chem, 244:5449-59. (PubMed:4981581)
4. Russell RL et al. (1963) Genetic control of hepatic delta-aminolevulinate dehydratase in mice Genetics, 48:1033-39. (PubMed:14050799)
5. Suzuki H et al. (2001) Protein-protein interaction panel using mouse full-length cDNAs. Genome Res, 11:1758-65. (PubMed:11591653)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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