Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits calcium ion binding activity and cargo receptor activity. Involved in several processes, including circulatory system development; negative regulation of signal transduction; and positive regulation of transport. Localizes to external side of plasma membrane and integral component of plasma membrane. Is expressed in several structures, including brain; extraembryonic component; face; genitourinary system; and intestine. Used to study Alzheimer's disease; cardiomyopathy; congenital diaphragmatic hernia; gastroschisis; and omphalocele. Human ortholog(s) of this gene implicated in Alzheimer's disease; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1).