Automated description from the Alliance of Genome Resources
Exhibits calcium ion binding activity and cargo receptor activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; circulatory system development; and negative regulation of signal transduction. Localizes to the integral component of plasma membrane. Used to study Alzheimer's disease; cardiomyopathy; congenital diaphragmatic hernia; gastroschisis; and omphalocele. Human ortholog(s) of this gene implicated in Alzheimer's disease; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1).