Automated description from the Alliance of Genome Resources (Release 3.1.1)
Exhibits lipopolysaccharide immune receptor activity. Involved in several processes, including regulation of cytokine production; regulation of intracellular signal transduction; and response to bacterium. Localizes to plasma membrane and receptor complex. Predicted to colocalize with membrane raft. Is expressed in cumulus oophorus; early embryo; inner cell mass; and intestine. Used to study pulmonary emphysema. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); eye disease (multiple); lung disease (multiple); and vasculitis (multiple). Orthologous to human TLR4 (toll like receptor 4).