Automated description from the Alliance of Genome Resources
Predicted to have several functions, including lipopolysaccharide binding activity; lipopolysaccharide receptor activity; and protein heterodimerization activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of cytokine production; and positive regulation of intracellular signal transduction. Localizes to the plasma membrane. Predicted to colocalize with the membrane raft. Used to study pulmonary emphysema. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetes mellitus (multiple); eye disease (multiple); lung disease (multiple); and vasculitis (multiple). Orthologous to human TLR4 (toll like receptor 4).