Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 8.3.0)

Enables lipopolysaccharide immune receptor activity. Involved in several processes, including positive regulation of defense response; regulation of cytokine production; and response to lipopolysaccharide. Acts upstream of or within several processes, including positive regulation of biosynthetic process; positive regulation of intracellular signal transduction; and response to bacterium. Located in plasma membrane. Part of receptor complex. Is expressed in several structures, including brain; early embryo; genitourinary system; intestine; and lung. Used to study pulmonary emphysema. Human ortholog(s) of this gene implicated in several diseases, including allergic contact dermatitis (multiple); artery disease (multiple); eye disease (multiple); lung disease (multiple); and vasculitis (multiple). Orthologous to human TLR4 (toll like receptor 4).

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Gene Ontology Evidence Code Abbreviations:

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