Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lmnb1. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). [provided by RefSeq, Oct 2010]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Lmnb1
  • is located in the following cellular components:
    • lamin filament ^[5]
    • nuclear envelope ^{[4, 6, 7]}
    • nucleoplasm ^[4]
    • nucleus ^{[1, 2, 3]}
• Researchers have inferred, based on physical interactions, that the gene product of Lmnb1
  • performs the following molecular functions:
    • phospholipase binding ^[4]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Lmnb1:
  • is located in the following cellular components:
    • nuclear matrix

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Summary text based on GO annotations supported by structural data

• Lmnb1 encodes a protein or proteins that contain the following InterPro domains: Filament, Intermediate filament protein, Intermediate filament protein, conserved site, Lamin Tail Domain, indicating that the gene product:
  • performs the following molecular functions:
    • structural molecule activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Lmnb1 indicates that it:
  • is located in the following cellular components:
    • intermediate filament
    • membrane

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References

1. Burns KH et al. (2003) Roles of NPM2 in chromatin and nucleolar organization in oocytes and embryos. Science, 300:633-6. (PubMed:12714744)
2. Chang M et al. (2011) The ubiquitin ligase Peli1 negatively regulates T cell activation and prevents autoimmunity. Nat Immunol, 12:1002-9. (PubMed:21874024)
3. Davis H et al. (2011) FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development. J Pathol, 224:180-9. (PubMed:21503901)
4. Fiume R et al. (2009) Involvement of nuclear PLCbeta1 in lamin B1 phosphorylation and G2/M cell cycle progression. FASEB J, 23:957-66. (PubMed:19028838)
5. Furukawa K et al. (1994) cDNA cloning and functional characterization of a meiosis-specific protein (MNS1) with apparent nuclear association. Chromosome Res, 2:99-113. (PubMed:8032679)
6. Goodchild RE et al. (2005) Loss of the dystonia-associated protein torsinA selectively disrupts the neuronal nuclear envelope. Neuron, 48:923-32. (PubMed:16364897)
7. Kim CE et al. (2010) A molecular mechanism underlying the neural-specific defect in torsinA mutant mice. Proc Natl Acad Sci U S A, 107:9861-6. (PubMed:20457914)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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