Automated description from the Alliance of Genome Resources (Release 3.0)
Predicted to have identical protein binding activity and protein phosphatase 1 binding activity. Involved in several processes, including negative regulation of apoptotic signaling pathway; negative regulation of cardiac muscle hypertrophy in response to stress; and positive regulation of macromolecule metabolic process. Localizes to lamin filament and nuclear membrane. Used to study several diseases, including Charcot-Marie-Tooth disease type 2B1; achalasia; dilated cardiomyopathy 1A; muscular dystrophy (multiple); and progeria. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscular dystrophy (multiple); and type 2 diabetes mellitus (multiple). Is expressed in several structures, including dorsal aorta; embryo mesenchyme; heart; intercostal muscle; and secondary oocyte. Orthologous to human LMNA (lamin A/C).