Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lhcgr. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred from direct assay, that the gene product of Lhcgr
  • participates in the following biological processes:
    • activation of adenylate cyclase activity ^[1]
    • cellular response to gonadotropin stimulus ^[1]
    • phospholipase C-activating G-protein coupled receptor signaling pathway ^[1]
    • positive regulation of cAMP-mediated signaling ^[1]
    • positive regulation of inositol trisphosphate biosynthetic process ^[1]
  • performs the following molecular functions:
    • choriogonadotropin hormone binding ^[1]
    • choriogonadotropin hormone receptor activity ^[1]
  • is located in the following cellular components:
    • integral to plasma membrane ^[1]
• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Lhcgr
  • participates in the following biological processes:
    • development of secondary male sexual characteristics ^[3]
    • female gonad development ^{[2, 3]}
    • male gonad development ^[3]
    • ovarian follicle development ^[3]
    • ovulation cycle process ^[3]
    • regulation of steroid hormone biosynthetic process ^[3]
    • seminiferous tubule development ^[3]
    • spermatogenesis ^[3]
    • uterus development ^[3]
  • performs the following molecular functions:
    • choriogonadotropin hormone receptor activity ^[3]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Lhcgr:
  • participates in the following biological processes:
    • activation of adenylate cyclase activity
    • adenylate cyclase-modulating G-protein coupled receptor signaling pathway
    • arachidonic acid secretion
    • hormone-mediated signaling pathway
    • luteinizing hormone signaling pathway
    • phospholipase C-activating G-protein coupled receptor signaling pathway
    • positive regulation of calcium ion transport into cytosol
    • positive regulation of calcium-mediated signaling
    • positive regulation of hormone biosynthetic process
    • positive regulation of release of sequestered calcium ion into cytosol
    • protein targeting to lysosome
  • performs the following molecular functions:
    • ATPase binding
    • G-protein coupled peptide receptor activity
    • identical protein binding
    • peptide hormone binding
    • protein homodimerization activity
  • is located in the following cellular components:
    • cytoplasm
    • endoplasmic reticulum
    • endosome
    • extracellular space
    • integral to plasma membrane
    • intrinsic to external side of plasma membrane
    • lysosome
    • nucleus
    • plasma membrane
    • receptor complex

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Summary text based on GO annotations supported by structural data

• Lhcgr encodes a protein or proteins that contain the following InterPro domains: Glycoprotein hormone receptor, GPCR, rhodopsin-like, GPCR, rhodopsin-like, 7TM, Leucine-rich repeat-containing N-terminal, Lutropin-choriogonadotropic hormone receptor, indicating that the gene product:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
  • performs the following molecular functions:
    • protein-hormone receptor activity
  • is located in the following cellular components:
    • integral to membrane

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Lhcgr indicates that it:
  • participates in the following biological processes:
    • G-protein coupled receptor signaling pathway
    • signal transduction
  • performs the following molecular functions:
    • G-protein coupled receptor activity
    • signal transducer activity
  • is located in the following cellular components:
    • integral to membrane
    • membrane

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References

1. Kuhn B et al. (1999) The luteinizing hormone receptor activates phospholipase C via preferential coupling to Gi2. Biochemistry, 38:12490-8. (PubMed:10493819)
2. Pakarainen T et al. (2005) Fertility in luteinizing hormone receptor-knockout mice after wild-type ovary transplantation demonstrates redundancy of extragonadal luteinizing hormone action. J Clin Invest, 115:1862-8. (PubMed:15951841)
3. Zhang FP et al. (2001) Normal prenatal but arrested postnatal sexual development of luteinizing hormone receptor knockout (LuRKO) mice. Mol Endocrinol, 15:172-83. (PubMed:11145748)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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