Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables DNA binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and chromatin binding activity. Involved in several processes, including T-helper 1 cell differentiation; positive regulation of cell differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including blood vessel morphogenesis; brain development; and embryonic morphogenesis. Located in cytoplasm and nucleus. Part of beta-catenin-TCF complex. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to human LEF1 (lymphoid enhancer binding factor 1).