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Gene Ontology Classifications
lymphoid enhancer binding factor 1

Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Lef1. (This text reflects annotations as of Tuesday, May 26, 2015.)
Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Summary text based on GO annotations supported by experimental evidence in mouse
Summary text based on GO annotations supported by experimental evidence in other organisms
Summary text for additional MGI annotations
  1. Benchabane H et al. (2011) Jerky/Earthbound facilitates cell-specific Wnt/Wingless signalling by modulating beta-catenin-TCF activity. EMBO J, 30:1444-58. (PubMed:21399610)
  2. Boras K et al. (2002) Alx4 binding to LEF-1 regulates N-CAM promoter activity. J Biol Chem, 277:1120-7. (PubMed:11696550)
  3. Boras-Granic K et al. (2006) Lef1 is required for the transition of Wnt signaling from mesenchymal to epithelial cells in the mouse embryonic mammary gland. Dev Biol, 295:219-31. (PubMed:16678815)
  4. Borello U et al. (2006) The Wnt/{beta}-catenin pathway regulates Gli-mediated Myf5 expression during somitogenesis. Development, 133:3723-32. (PubMed:16936075)
  5. Brugmann SA et al. (2007) Wnt signaling mediates regional specification in the vertebrate face. Development, 134:3283-95. (PubMed:17699607)
  6. Chalamalasetty RB et al. (2011) The Wnt3a/beta-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program. Nat Commun, 2:390. (PubMed:21750544)
  7. Choi HJ et al. (2006) Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. J Biol Chem, 281:1027-38. (PubMed:16293619)
  8. Dai D et al. (2013) Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia. Cell Death Differ, 20:130-8. (PubMed:22935613)
  9. DasGupta R et al. (1999) Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development, 126:4557-68. (PubMed:10498690)
  10. Dassule HR et al. (1998) Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev Biol, 202:215-27. (PubMed:9769173)
  11. Duan D et al. (1999) Submucosal gland development in the airway is controlled by lymphoid enhancer binding factor 1 (LEF1). Development, 126:4441-53. (PubMed:10498680)
  12. Galceran J et al. (2000) Hippocampus development and generation of dentate gyrus granule cells is regulated by LEF1. Development, 127:469-82. (PubMed:10631168)
  13. Galceran J et al. (1999) Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-) mice. Genes Dev, 13:709-17. (PubMed:10090727)
  14. Galceran J et al. (2004) LEF1-mediated regulation of Delta-like1 links Wnt and Notch signaling in somitogenesis. Genes Dev, 18:2718-23. (PubMed:15545629)
  15. Giese K et al. (1995) Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev, 9:995-1008. (PubMed:7774816)
  16. Goodall J et al. (2004) Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin. Mol Cell Biol, 24:2915-22. (PubMed:15024079)
  17. Hasenpusch-Theil K et al. (2012) Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus. Cereb Cortex, 22:2878-93. (PubMed:22235033)
  18. Hebenstreit D et al. (2008) LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element. J Biol Chem, 283:22490-7. (PubMed:18579517)
  19. Iwatsuki K et al. (2007) Wnt signaling interacts with Shh to regulate taste papilla development. Proc Natl Acad Sci U S A, 104:2253-8. (PubMed:17284610)
  20. Jin ZX et al. (2002) Lymphoid enhancer-binding factor-1 binds and activates the recombination-activating gene-2 promoter together with c-Myb and Pax-5 in immature B cells. J Immunol, 169:3783-92. (PubMed:12244173)
  21. Kahler RA et al. (2003) Lymphoid enhancer factor-1 and beta-catenin inhibit Runx2-dependent transcriptional activation of the osteocalcin promoter. J Biol Chem, 278:11937-44. (PubMed:12551949)
  22. Kratochwil K et al. (2002) FGF4, a direct target of LEF1 and Wnt signaling, can rescue the arrest of tooth organogenesis in Lef1(-/-) mice. Genes Dev, 16:3173-85. (PubMed:12502739)
  23. Lang D et al. (2005) Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature, 433:884-7. (PubMed:15729346)
  24. Liu X et al. (2010) Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promoter. Am J Physiol Lung Cell Mol Physiol, 299:L694-710. (PubMed:20802155)
  25. Lobov IB et al. (2005) WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature, 437:417-21. (PubMed:16163358)
  26. Michno K et al. (2003) Shh expression is required for embryonic hair follicle but not mammary gland development. Dev Biol, 264:153-65. (PubMed:14623238)
  27. Miranda-Carboni GA et al. (2008) A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors. Genes Dev, 22:3121-34. (PubMed:19056892)
  28. Nawshad A et al. (2003) TGF{beta}3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development. J Cell Biol, 163:1291-1301. (PubMed:14691138)
  29. Okamura RM et al. (1998) Redundant regulation of T cell differentiation and TCRalpha gene expression by the transcription factors LEF-1 and TCF-1. Immunity, 8:11-20. (PubMed:9462507)
  30. Olson LE et al. (2006) Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell, 125:593-605. (PubMed:16678101)
  31. Osorio KM et al. (2011) Runx1 modulates adult hair follicle stem cell emergence and maintenance from distinct embryonic skin compartments. J Cell Biol, 193:235-50. (PubMed:21464233)
  32. Phng LK et al. (2009) Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. Dev Cell, 16:70-82. (PubMed:19154719)
  33. Ray S et al. (2008) Cooperative Control via Lymphoid Enhancer Factor 1/T Cell Factor 3 and Estrogen Receptor-{alpha} for Uterine Gene Regulation by Estrogen. Mol Endocrinol, 22:1125-40. (PubMed:18202148)
  34. Reya T et al. (2000) Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity, 13:15-24. (PubMed:10933391)
  35. Sachdev S et al. (2001) PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies. Genes Dev, 15:3088-103. (PubMed:11731474)
  36. Sasaki T et al. (2005) LEF1 is a critical epithelial survival factor during tooth morphogenesis. Dev Biol, 278:130-43. (PubMed:15649466)
  37. Spater D et al. (2006) Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis. Development, 133:3039-49. (PubMed:16818445)
  38. Surendran K et al. (2003) CNP gene expression is activated by Wnt signaling and correlates with Wnt4 expression during renal injury. Am J Physiol Renal Physiol, 284:F653-62. (PubMed:12475749)
  39. Wu CX et al. (2004) Activation of mouse RAG-2 promoter by Myc-associated zinc finger protein. Biochem Biophys Res Commun, 317:1096-102. (PubMed:15094381)
  40. Wu X et al. (2006) Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin. Genes Dev, 20:571-85. (PubMed:16510873)
  41. Zhou CJ et al. (2004) Wnt signaling mutants have decreased dentate granule cell production and radial glial scaffolding abnormalities. J Neurosci, 24:121-6. (PubMed:14715945)
  42. Zhou P et al. (1995) Lymphoid enhancer factor 1 directs hair follicle patterning and epithelial cell fate. Genes Dev, 9:700-13. (PubMed:7537238)

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Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IAS Inferred from ancestral sequence
  IBA Inferred from biological aspect of ancestor
  IBD Inferred from biological aspect of descendant
  IC Inferred by curator
  IDA Inferred from direct assay
  IEA Inferred from electronic annotation
  IGI Inferred from genetic interaction
  IKR Inferred from key residues
  IMP Inferred from mutant phenotype
  IMR Inferred from missing residues
  IPI Inferred from physical interaction
  IRD Inferred from rapid divergence
  ISS Inferred from sequence or structural similarity
  ISO Inferred from sequence orthology
  ISA Inferred from sequence alignment
  ISM Inferred from sequence model
  NAS Non-traceable author statement
  ND No biological data available
  RCA Reviewed computational analysis
  TAS Traceable author statement


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