Automated description from the Alliance of Genome Resources
Exhibits amyloid-beta binding activity; lipoprotein particle receptor activity; and low-density lipoprotein particle binding activity. Involved in several processes, including lipid transport; regulation of inflammatory response; and regulation of lipid metabolic process. Localizes to several cellular components, including the basolateral plasma membrane; cell; and endosome. Used to study familial hypercholesterolemia and fatty liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; paravertebral ganglion; and ventral grey horn. Orthologous to human LDLR (low density lipoprotein receptor).