Go Annotations as Summary Text (Tabular View) (GO Graph)

GO curators for mouse genes have assigned the following annotations to the gene product of Krt9. (This text reflects annotations as of Wednesday, January 23, 2013.)

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Summary from NCBI RefSeq

[Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the type I keratin 9, an intermediate filament chain expressed only in the terminally differentiated epidermis of palms and soles. Mutations in this gene cause epidermolytic palmoplantar keratoderma. [provided by RefSeq, Jul 2008]

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Summary text based on GO annotations supported by experimental evidence in mouse

• Researchers have inferred, based on phenotypic analysis of mouse mutants, that the gene product of Krt9
  • participates in the following biological processes:
    • spermatogenesis ^[1]

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Summary text based on GO annotations supported by experimental evidence in other organisms

• From comparative sequence analysis (see table for details), MGI curators have determined that the gene product of Krt9:
  • participates in the following biological processes:
    • intermediate filament organization
    • skin development
    • spermatogenesis
  • is located in the following cellular components:
    • keratin filament
    • perinuclear region of cytoplasm

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Summary text based on GO annotations supported by structural data

• Krt9 encodes a protein or proteins that contain the following InterPro domains: Filament, Intermediate filament protein, Keratin, type I, indicating that the gene product:
  • performs the following molecular functions:
    • structural molecule activity

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Summary text for additional MGI annotations

• Automated translation to GO terms of SwissProt keywords that describe Krt9 indicates that it:
  • is located in the following cellular components:
    • intermediate filament

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References

1. Rivkin E et al. (2005) Sperm tail abnormalities in mutant mice with neo(r) gene insertion into an intron of the keratin 9 gene. Mol Reprod Dev, 72:259-71. (PubMed:16015579)

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Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IC Inferred by curator

IDA Inferred from direct assay

IEA Inferred from electronic annotation

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

ISS Inferred from sequence or structural similarity

ISO Inferred from sequence orthology

ISA Inferred from sequence alignment

ISM Inferred from sequence model

NAS Non-traceable author statement

ND No biological data available

RCA Reviewed computational analysis

TAS Traceable author statement

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